Phosphatases and solid tumors: focus on glioblastoma initiation, progression and recurrences

M Dedobbeleer, E Willems, S Freeman… - Biochemical …, 2017 - portlandpress.com
Phosphatases and cancer have been related for many years now, as these enzymes
regulate key cellular functions, including cell survival, migration, differentiation and …

Novel Immunotherapeutic Approaches for the Treatment of Glioblastoma

SE Zaidi, E Moelker, K Singh, A Mohan, MA Salgado… - BioDrugs, 2023 - Springer
Glioblastoma is highly aggressive and remains difficult to treat despite being the most
common malignant primary brain tumor in adults. Current standard-of-care treatment calls …

Glioma cell and astrocyte co-cultures as a model to study tumor–tissue interactions: A review of methods

IV Chekhonin, DA Chistiakov, NF Grinenko… - Cellular and molecular …, 2018 - Springer
Astrocytes are a dominant cell type that envelopes the glioma bed. Typically, that is followed
by formation of contacts between astrocytes and glioma cells and accompanied by change …

[HTML][HTML] Light-controlled crosslinked multifunctional" Band-Aids" as dual-stage wound dressing for dynamic wound closure

X Zhang, X Zhan, C Hu, Z Dong, T Luo, H Li, X Fan… - Collagen and …, 2024 - Springer
The objective of regenerative wound healing dressings is to accelerate skin tissue
regeneration and restore normal physiological function at wound sites. Achieving this goal …

[HTML][HTML] Drug resistance in glioblastoma: from chemo-to immunotherapy

S Sharma, O Chepurna, T Sun - Cancer Drug Resistance, 2023 - ncbi.nlm.nih.gov
As the most common and aggressive type of primary brain tumor in adults, glioblastoma is
estimated to end over 10,000 lives each year in the United States alone. Stand treatment for …

Large scale identification of variant proteins in glioma stem cells

E Mostovenko, Á Végvári, M Rezeli… - ACS chemical …, 2018 - ACS Publications
Glioblastoma (GBM), the most malignant of primary brain tumors, is a devastating and
deadly disease, with a median survival of 14 months from diagnosis, despite standard …

Rab27b contributes to radioresistance and exerts a paracrine effect via epiregulin in glioblastoma

S Nishioka, PH Wu, T Yakabe, AJ Giaccia… - Neuro-Oncology …, 2020 - academic.oup.com
Background Radiotherapy is the standard treatment for glioblastoma (GBM). However,
radioresistance of GBM cells leads to recurrence and poor patient prognosis. Recent studies …

Radiation-induced G2/M arrest rarely occurred in glioblastoma stem-like cells

J Liu, Y Liu, T Xie, L Luo, C Xu, Q Gao… - … Journal of Radiation …, 2018 - Taylor & Francis
Purpose: The purpose of this study is to systematically study the cell-cycle alterations of
glioblastoma stem-like cells (GSLCs) after irradiation, possibly enriching the mechanisms of …

[HTML][HTML] M2 receptor activation counteracts the glioblastoma cancer stem cell response to hypoxia condition

I Cristofaro, C Limongi, P Piscopo, A Crestini… - International Journal of …, 2020 - mdpi.com
Glioblastoma multiforme (GBM) is the most malignant brain tumor. Hypoxic condition is a
predominant feature of the GBM contributing to tumor growth and resistance to conventional …

[HTML][HTML] Players of 'hypoxia orchestra'–what is the role of FMISO?

T Toyonaga, K Hirata, T Shiga, T Nagara - European Journal of Nuclear …, 2017 - Springer
Hypoxia is one of the most important factors for exacerbating malignancy, including brain
tumors [1–3]. Hypoxia induces radioresistance [4], chemoresistance [5], HRE-related gene …