Scalable production of extracellular vesicles and its therapeutic values: a review

CY Ng, LT Kee, ME Al-Masawa, QH Lee… - International Journal of …, 2022 - mdpi.com
Extracellular vesicles (EVs) are minute vesicles with lipid bilayer membranes. EVs are
secreted by cells for intercellular communication. Recently, EVs have received much …

Hypoxia-responsive nanoparticle based drug delivery systems in cancer therapy: an up-to-date review

R Kumari, D Sunil, RS Ningthoujam - Journal of Controlled Release, 2020 - Elsevier
Hypoxia is a salient feature observed in most solid malignancies that holds a pivotal role in
angiogenesis, metastasis and resistance to conventional cancer therapeutic approaches …

Mesenchymal stem cell therapy for osteoarthritis: the critical role of the cell secretome

P Mancuso, S Raman, A Glynn, F Barry… - … in bioengineering and …, 2019 - frontiersin.org
Osteoarthritis (OA) is an inflammatory condition still lacking effective treatments.
Mesenchymal stem/stromal cells (MSCs) have been successfully employed in pre-clinical …

Nanoparticle elasticity regulates the formation of cell membrane-coated nanoparticles and their nano-bio interactions

D Zou, Z Wu, X Yi, Y Hui, G Yang… - Proceedings of the …, 2023 - National Acad Sciences
Cell membrane-coated nanoparticles are emerging as a new type of promising
nanomaterials for immune evasion and targeted delivery. An underlying premise is that the …

The role of COX-2 and PGE2 in the regulation of immunomodulation and other functions of mesenchymal stromal cells

A Kulesza, L Paczek, A Burdzinska - Biomedicines, 2023 - mdpi.com
The ability of MSCs to modulate the inflammatory environment is well recognized, but
understanding the molecular mechanisms responsible for these properties is still far from …

Mechanisms of mesenchymal stromal cell immunomodulation

K English - Immunology and cell biology, 2013 - Wiley Online Library
Multipotent mesenchymal stromal cells (MSCs) have generated considerable interest in the
fields of regenerative medicine, cell therapy and immune modulation. Over the past 5 years …

Improved therapeutics of modified mesenchymal stem cells: an update

DKW Ocansey, B Pei, Y Yan, H Qian, X Zhang… - Journal of translational …, 2020 - Springer
Abstract Background Mesenchymal stromal cells (MSCs) have attracted intense interest due
to their powerful intrinsic properties of self-regeneration, immunomodulation and multi …

Mesenchymal stem cells in tissue repair

AM DiMarino, AI Caplan, TL Bonfield - Frontiers in immunology, 2013 - frontiersin.org
The advent of mesenchymal stem cell (MSC)-based therapies for clinical therapeutics has
been an exciting and new innovation for the treatment of a variety of diseases associated …

Small extracellular vesicles secreted by human iPSC-derived MSC enhance angiogenesis through inhibiting STAT3-dependent autophagy in ischemic stroke

Y Xia, X Ling, G Hu, Q Zhu, J Zhang, Q Li… - Stem cell research & …, 2020 - Springer
Background Small extracellular vesicles (sEV) secreted by mesenchymal stem cells (MSC)
derived from human induced pluripotent stem cells (iPSC, iMSC-sEV) are considered to …

Enhancing the migration ability of mesenchymal stromal cells by targeting the SDF‐1/CXCR4 axis

LA Marquez-Curtis… - BioMed research …, 2013 - Wiley Online Library
Mesenchymal stromal cells (MSCs) are currently being investigated in numerous clinical
trials of tissue repair and various immunological disorders based on their ability to secrete …