Antibiotic resistance is becoming a burning issue due to the frequent use of antibiotics for
curing common bacterial infections, indicating that we are running out of effective antibiotics …

Genomic analysis has demonstrated that many fungi possess essential gene clusters for the
production of previously unobserved secondary metabolites; however, these genes are …

DNA methyltransferases (DNMTs) are a group of proteins that catalyze DNA methylation by
transferring a methyl group to DNA. The genetic variation in DNMTs results in differential …

The in-depth study of fungal secondary metabolites (SMs) over the past few years has led to
the discovery of a vast number of novel fungal SMs, some of which possess good biological …

Alternaria dauci is a Dothideomycete fungus, causal agent of carrot leaf blight. As a member
of the Alternaria genus, known to produce a lot of secondary metabolite toxins, A. dauci is …

Natural products have been playing an indispensable role in drug discovery. However, it
seems that the golden period of discovering new compounds has passed since the first …

The host–pathogen interaction is a multifactorial process subject to a co-evolutionary arms
race consisting of rapid changes in both host and pathogen, controlled at the genetic and …

The isolation and identification of an increasing number of secondary metabolites featuring
unique skeletons and possessing diverse bioactivities sourced from marine microorganisms …

Main conclusion We discovered and identified a series of characteristic substances,
including one new polyketide, epicorepoxydon B, of the important pathogenic fungus …

Scientists are making efforts to search for new metabolites as they are essential lead
molecules for the drug discovery, much required due to the evolution of multi drug resistance …