The endoplasmic reticulum (ER) is a dynamic and multifunctional organelle responsible for
protein biosynthesis, folding, assembly and modifications. Loss of protein folding regulation …

Diabetic kidney disease (DKD) is a major cause of end-stage kidney disease, and it is
crucial to understand the pathophysiology of DKD. The control of blood glucose levels by …

Disturbance of endoplasmic reticulum (ER) homeostasis triggered by the accumulation of
unfolded proteins and advanced glycation end-products (AGEs) plays a major role in …

Endoplasmic reticulum (ER) stress, resulting from the accumulation of misfolded and/or
unfolded proteins in ER membranes, is involved in the pathogenesis of diabetic …

Abstract Purpose of Review Diabetic nephropathy (DN) has become the leading cause of
end-stage renal disease (ESRD) worldwide. Accumulating evidence suggests that …

The role of endoplasmic reticulum stress and the unfolded pr... : Current Opinion in
Rheumatology The role of endoplasmic reticulum stress and the unfolded protein response in …

The clinical relationship between diabetes and inflammation is well established. Evidence
clearly indicates that disrupting oxidant-antioxidant equilibrium and elevated lipid …

The endoplasmic reticulum (ER) folds and modifies proteins; however, during conditions of
cellular stress, unfolded proteins accumulate in the ER and activate the unfolded protein …

Diabetes mellitus is associated with a high production of reactive oxygen species, which
may cause oxidative DNA damage. High levels of genomic damage have been associated …

Microalbuminuria provides the earliest clinical marker of diabetic nephropathy among
patients with Type 1 diabetes, yet it lacks sensitivity and specificity for early histological …