CCAAT/enhancer-binding proteins (C/EBPs) are a family of at least six identified
transcription factors that contain a highly conserved basic leucine zipper domain and …

Several animal studies have shown an important role for endoplasmic reticulum (ER) stress
in AKI, whereas human studies are lacking. We recently reported that Reticulon-1A (RTN1A) …

Pathological insults usually disturb the folding capacity of cellular proteins and lead to the
accumulation of misfolded proteins in the endoplasmic reticulum (ER), which leads to so …

The prevalence of diabetic nephropathy continues to rise, highlighting the importance of
investigating and discovering novel treatment strategies. TRB3 is a kinase-like molecule that …

The rapid growth of the elderly population is making the need for extensive and advanced
information about age-related organ dysfunction a crucial research area. The kidney is one …

Uremic toxins can deteriorate renal function, but little is known about its mechanism.
Because tubular injury is central to progression of chronic kidney disease (CKD), we …

Background Maladaptive endoplasmic reticulum stress signaling in diabetic kidney disease
(DKD) is linked to increased glomerular and tubular expression of the cell-death–promoting …

Diabetic kidney disease is the leading worldwide cause of end stage kidney disease and a
growing public health challenge. The diabetic kidney is exposed to many environmental …

Diabetes mellitus is the leading chronic disease in the world, and diabetic nephropathy (DN)
as one of its complications could increase the mortality. The development of DN is …

Objective—The endoplasmic reticulum (ER) plays a critical role in ensuring proper folding of
newly synthesized proteins. Aberrant ER stress is reported to play a causal role in …