[HTML][HTML] mRNA-based therapeutics: powerful and versatile tools to combat diseases

S Qin, X Tang, Y Chen, K Chen, N Fan… - Signal transduction and …, 2022 - nature.com
The therapeutic use of messenger RNA (mRNA) has fueled great hope to combat a wide
range of incurable diseases. Recent rapid advances in biotechnology and molecular …

[HTML][HTML] The functional roles of the circRNA/Wnt axis in cancer

C Xue, G Li, Q Zheng, X Gu, Z Bao, J Lu, L Li - Molecular Cancer, 2022 - Springer
CircRNAs, covalently closed noncoding RNAs, are widely expressed in a wide range of
species ranging from viruses to plants to mammals. CircRNAs were enriched in the Wnt …

[HTML][HTML] The FUS/circEZH2/KLF5/feedback loop contributes to CXCR4-induced liver metastasis of breast cancer by enhancing epithelial-mesenchymal transition

P Liu, Z Wang, X Ou, P Wu, Y Zhang, S Wu, X Xiao… - Molecular cancer, 2022 - Springer
Background Metastasis of breast cancer have caused the majority of cancer-related death
worldwide. The circRNAs are associated with tumorigenesis and metastasis in breast cancer …

[HTML][HTML] Exosome-derived circCCAR1 promotes CD8+ T-cell dysfunction and anti-PD1 resistance in hepatocellular carcinoma

Z Hu, G Chen, Y Zhao, H Gao, L Li, Y Yin, J Jiang… - Molecular Cancer, 2023 - Springer
Abstract Background Circular RNAs (circRNAs) can be encapsulated into exosomes to
participate in intercellular communication, affecting the malignant progression of a variety of …

[HTML][HTML] M6A-mediated upregulation of circMDK promotes tumorigenesis and acts as a nanotherapeutic target in hepatocellular carcinoma

A Du, S Li, Y Zhou, C Disoma, Y Liao, Y Zhang… - Molecular Cancer, 2022 - Springer
Background Emerging evidence suggest the critical role of circular RNAs (circRNAs) in
disease development especially in various cancers. However, the oncogenic role of …

Essential roles of exosome and circRNA_101093 on ferroptosis desensitization in lung adenocarcinoma

X Zhang, Y Xu, L Ma, K Yu, Y Niu, X Xu… - Cancer …, 2022 - Wiley Online Library
Background Resistance to ferroptosis, a regulated cell death caused by iron‐dependent
excessive accumulation of lipid peroxides, has recently been linked to lung adenocarcinoma …

[HTML][HTML] Hsa_circ_0003258 promotes prostate cancer metastasis by complexing with IGF2BP3 and sponging miR-653-5p

YZ Yu, DJ Lv, C Wang, XL Song, T Xie, T Wang, ZM Li… - Molecular cancer, 2022 - Springer
Background More and more studies have shown that circular RNAs (circRNAs) play a critical
regulatory role in many cancers. However, the potential molecular mechanism of circRNAs …

Exosomal circular RNAs: A chief culprit in cancer chemotherapy resistance

X Guo, C Gao, DH Yang, S Li - Drug Resistance Updates, 2023 - Elsevier
Chemotherapy is one of the primary treatments for malignant tumors. However, the acquired
drug resistance hinders clinical efficacy and leads to treatment failure in most patients …

[HTML][HTML] Vaccine technologies and platforms for infectious diseases: Current progress, challenges, and opportunities

M Ghattas, G Dwivedi, M Lavertu, MG Alameh - Vaccines, 2021 - mdpi.com
Vaccination is a key component of public health policy with demonstrated cost-effective
benefits in protecting both human and animal populations. Vaccines can be manufactured …

EIF4A3-induced circARHGAP29 promotes aerobic glycolysis in docetaxel-resistant prostate cancer through IGF2BP2/c-Myc/LDHA signaling

X Jiang, S Guo, S Wang, Y Zhang, H Chen, Y Wang… - Cancer research, 2022 - AACR
Docetaxel-based chemotherapy is a standard-of-care treatment for metastatic prostate
cancer, and chemoresistance remains a major challenge in clinical practice. Recent studies …