COVID-19-associated fungal infections

M Hoenigl, D Seidel, R Sprute, C Cunha… - Nature …, 2022 - nature.com
Abstract Coronavirus disease 2019 (COVID-19)-associated invasive fungal infections are an
important complication in a substantial number of critically ill, hospitalized patients with …

[HTML][HTML] COVID-19 and tuberculosis: the double whammy of respiratory pathogens

M Shariq, JA Sheikh, N Quadir… - European …, 2022 - Eur Respiratory Soc
Prior to coronavirus disease 2019 (COVID-19), tuberculosis (TB) was the worst killer among
infectious diseases. The union of these two obnoxious respiratory diseases can be …

Persistent Oxidative Stress and Inflammasome Activation in CD14highCD16 Monocytes From COVID-19 Patients

SL Lage, EP Amaral, KL Hilligan, E Laidlaw… - Frontiers in …, 2022 - frontiersin.org
The poor outcome of the coronavirus disease-2019 (COVID-19), caused by SARS-CoV-2, is
associated with systemic hyperinflammatory response and immunopathology. Although …

Ventilator-associated pneumonia among SARS-CoV-2 acute respiratory distress syndrome patients

J Fumagalli, M Panigada, M Klompas… - Current opinion in …, 2022 - journals.lww.com
Covid-19 patients who require mechanical ventilation for ARDS have a high risk (> 50%) of
developing VAP, most commonly because of Gram-negative bacteria. Further work is …

Infection of lung megakaryocytes and platelets by SARS-CoV-2 anticipate fatal COVID-19

A Zhu, F Real, C Capron, AR Rosenberg… - Cellular and Molecular …, 2022 - Springer
Abstract SARS-CoV-2, although not being a circulatory virus, spread from the respiratory
tract resulting in multiorgan failures and thrombotic complications, the hallmarks of fatal …

Modulation of macrophage polarization by viruses: turning off/on host antiviral responses

S Yu, H Ge, S Li, HJ Qiu - Frontiers in microbiology, 2022 - frontiersin.org
Macrophages are professional antigen-presenting cells and serve as the first line of defense
against invading pathogens. Macrophages are polarized toward the proinflammatory …

CD169-mediated restrictive SARS-CoV-2 infection of macrophages induces pro-inflammatory responses

S Jalloh, J Olejnik, J Berrigan, A Nisa, EL Suder… - PLoS …, 2022 - journals.plos.org
Exacerbated and persistent innate immune response marked by pro-inflammatory cytokine
expression is thought to be a major driver of chronic COVID-19 pathology. Although …

Identification of immunomodulatory drugs that inhibit multiple inflammasomes and impair SARS-CoV-2 infection

L de Almeida, ALN da Silva, TS Rodrigues… - Science …, 2022 - science.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces mild or
asymptomatic COVID-19 in most cases, but some patients develop an excessive …

Human endogenous retrovirus K in the respiratory tract is associated with COVID-19 physiopathology

JR Temerozo, N Fintelman-Rodrigues, MC Dos Santos… - Microbiome, 2022 - Springer
Background Critically ill 2019 coronavirus disease (COVID-19) patients under invasive
mechanical ventilation (IMV) are 10 to 40 times more likely to die than the general …

The impact of coronavirus disease 2019 on viral, bacterial, and fungal respiratory infections

A Losier, G Gupta, M Caldararo… - Clinics in chest …, 2023 - chestmed.theclinics.com
Since the emergence of the coronavirus disease 2019 (COVID-19) pandemic in Wuhan,
China, in December 2019, there has been a significant focus placed on its transmission …