Human early development sets the stage for embryonic and adult life but remains difficult to
investigate. A solution came from the ability of stem cells to organize into structures …

Over the past few decades, many attempts have been made to capture different states of
pluripotency in vitro. Naive and primed pluripotent stem cells, corresponding to the …

Translational regulation plays a critical role during the oocyte-to-embryo transition (OET)
and zygotic genome activation (ZGA). Here, we integrated ultra-low-input ribosome profiling …

Summary H3K9me3, as a hallmark of heterochromatin, is important for cell-fate specification.
However, it remains unknown how H3K9me3 is reprogrammed during human early embryo …

In human embryos, major zygotic genome activation (ZGA) initiates at the eight-cell (8C)
stage. Abnormal ZGA leads to developmental defects and even contributes to the failure of …

Kidney organoids differentiated from pluripotent stem cells are powerful models of kidney
development and disease but are characterized by cell immaturity and off-target cell fates …

Human preimplantation development involves extensive remodeling of RNA expression and
splicing. However, its transcriptome has been compiled using short-read sequencing data …

Highlights•Cellular models can recapitulate some aspects of embryonic genome
activation.•Multiple factors regulate embryonic genome activation.•Several types of totipotent …

Embryonic genome activation (EGA) is critical for embryonic development. However, our
understanding of the regulatory mechanisms of human EGA is still incomplete. Human …

Studies of mammalian development have advanced our understanding of the genetic,
epigenetic, and cellular processes that orchestrate embryogenesis and have uncovered …