Emerging roles of astrocytes in blood-brain barrier disruption upon amyloid-beta insults in Alzheimer's disease

Q Yue, MPM Hoi - Neural Regeneration Research, 2023 - journals.lww.com
Blood-brain barrier disruption occurs in the early stages of Alzheimer's disease. Recent
studies indicate a link between blood-brain barrier dysfunction and cognitive decline and …

[HTML][HTML] Alzheimer's disease puzzle: delving into pathogenesis hypotheses

M Nasb, W Tao, N Chen - Aging and Disease, 2024 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is a prevalent neurodegenerative disease characterized by both
amnestic and non-amnestic clinical manifestations. It accounts for approximately 60-70% of …

Application of novel degraders employing autophagy for expediting medicinal research

X Li, Q Liu, X Xie, C Peng, Q Pang, B Liu… - Journal of Medicinal …, 2023 - ACS Publications
Targeted protein degradation (TPD) technology is based on a unique pharmacological
mechanism that has profoundly revolutionized medicinal research by overcoming limitations …

[HTML][HTML] Intersectionality in Alzheimer's disease: the role of female sex and Black American race in the development and prevalence of Alzheimer's disease

MB Misiura, B Butts, B Hammerschlag, C Munkombwe… - …, 2023 - Elsevier
It is well known that vascular factors and specific social determinants of health contribute to
dementia risk and that the prevalence of these risk factors differs according to race and sex …

Bone Marrow‐Derived GCA+ Immune Cells Drive Alzheimer's Disease Progression

R Zhou, L Wang, L Chen, X Feng, R Zhou… - Advanced …, 2023 - Wiley Online Library
Alzheimer's disease (AD) is an age‐related degenerative disease of the central nervous
system (CNS), whereas the role of bone marrow immune cells in the pathogenesis of AD …

Modeling the neuroimmune system in Alzheimer's and Parkinson's diseases

W Balestri, R Sharma, VA da Silva, BC Bobotis… - Journal of …, 2024 - Springer
Parkinson's disease (PD) and Alzheimer's disease (AD) are neurodegenerative disorders
caused by the interaction of genetic, environmental, and familial factors. These diseases …

Recent advances in Alzheimer's disease pathogenesis and therapeutics from an immune perspective

TD Nguyen, LN Dang, JH Jang, S Park - Journal of Pharmaceutical …, 2023 - Springer
Abstract Background The prevalence of Alzheimer's disease, the most common type of
dementia, is continuously increasing. Many recent reports have indicated that immune …

Membrane-active peptides and their potential biomedical application

A Gostaviceanu, S Gavrilaş, L Copolovici… - Pharmaceutics, 2023 - mdpi.com
Membrane-active peptides (MAPs) possess unique properties that make them valuable tools
for studying membrane structure and function and promising candidates for therapeutic …

Kallikrein-related peptidase's significance in Alzheimer's disease pathogenesis: A comprehensive survey

R Boumali, L Urli, M Naim, F Soualmia, K Kinugawa… - Biochimie, 2024 - Elsevier
Alzheimer's disease (AD) and related dementias constitute an important global health
challenge. Detailed understanding of the multiple molecular mechanisms underlying their …

Novel Therapeutic Strategies in Alzheimer's Disease: Pitfalls and Challenges of Anti-Amyloid Therapies and Beyond

G Tondo, F De Marchi, F Bonardi, F Menegon… - Journal of Clinical …, 2024 - mdpi.com
Alzheimer's disease (AD) causes a significant challenge to global healthcare systems, with
limited effective treatments available. This review examines the landscape of novel …