Gene expression changes in neuropsychiatric and neurodegenerative disorders, and gene
responses to therapeutic drugs, provide new ways to identify central nervous system (CNS) …

Aging is a complex biological process driven by a selective class of molecules and
pathways that affect overall deterioration of physiological functions to increase the risk of …

In this article, we have characterized and compared gene expression profiles from laser
capture microdissected neurons in six functionally and anatomically distinct regions from …

Dysfunction of cholinergic basal forebrain (CBF) neurons of the nucleus basalis (NB) is a
cardinal feature of Alzheimer's disease (AD) and correlates with cognitive decline. Survival …

Endocytic system dysfunction is one of the earliest disturbances that occur in Alzheimer's
disease (AD), and may underlie the selective vulnerability of cholinergic basal forebrain …

The senescence‐accelerated prone 8 (SAMP8) mouse strain shows early cognitive loss that
mimics the deterioration of learning and memory in the elderly and is widely used as an …

Molecular mechanisms underlying tauopathy remain undetermined. In the current study,
single cell gene expression profiling was coupled with custom‐designed cDNA array …

Although great effort has been put forth to uncover the complex molecular mechanisms
exploited in the pathogenesis of Parkinson's disease, a satisfactory explanation remains to …

We demonstrate that, contrary to current understanding, the density of probe molecules is
not responsible for the lack of hybridization in high density single-stranded DNA (ss-DNA) …

Cognitive processes associated with prefrontal cortex and hippocampus decline with age
and are vulnerable to disruption by stress. The stress/stress hormone/allostatic load …