Acute inflammation is a localized and self-limited innate host-defense mechanism against
invading pathogens and tissue injury. Neutrophils, the most abundant immune cells in …

The phagocytosis of dying cells by macrophages, termed efferocytosis, is a tightly regulated
process that involves the sensing, binding, engulfment, and digestion of apoptotic cells …

Cytokine storm is a phenomenon characterized by strong elevated circulating cytokines that
most often occur after an overreactive immune system is activated by an acute systemic …

A cytokine storm is an abnormal discharge of soluble mediators following an inappropriate
inflammatory response that leads to immunopathological events. Cytokine storms can occur …

Mesenchymal stem cells (MSCs) influence T cells in health, disease and therapy through
messengers of intercellular communication including extracellular vesicles (EVs). Apoptosis …

Sepsis-induced cardiomyopathy (SIC) is the main complication and a leading cause of
death in intensive care units. S100a8/a9 is a calcium-binding protein that participates in …

Acute liver injury (ALI) is recognized as a serious complication of sepsis in patients in
intensive care units (ICUs). S100A8/A9 is known to promote inflammation and immune …

Objective The pathogenesis of sepsis is complex, and the sepsis-induced systemic
proinflammatory phase is one of the key drivers of organ failure and consequent mortality …

Cardiac dysfunction is a common complication in patients with sepsis triggering high
morbidity and mortality. Lycorine (LYC), the main effective monomer component extracted …

The development of therapies for SARS-CoV-2 infection, based on virus biology and
pathology, and of large-and small-scale randomized controlled trials, have brought forward …