Although the recent FDA approval of six new antibody–drug conjugates (ADCs) is
promising, attrition of ADCs during clinical development remains high. The inherent …

Introduction: Peripheral neuropathy (PN) is an adverse effect of several classes of
chemotherapy including the taxanes. Predictive PN biomarkers could inform individualized …

Docetaxel (DTX) is one of the chemotherapeutic drugs indicated as a first-line treatment
against metastatic prostate cancer (mPCa). This study aimed to compare the impact of DTX …

Taxanes are a widely used class of anticancer agents that play a vital role in the treatment of
a variety of cancers. However, toxicity remains a major concern of using taxane drugs as …

Abstract What Is Known and Objective Drug‐induced neutropenia is the main reason for the
dose limitation of docetaxel in patients with breast cancer. The area under the drug …

This study reports the first clinical evidence of significantly high secretion of matrine in a
multi-component botanical (Antitumor B, ATB) into human saliva from the systemic …

Objective To investigate the influence of renal failure on the area under curve (AUC) and
adverse reactions of docetaxel in breast cancer patients, and provide evidence for the …

Simple Summary This is the first human study using saliva samples for drug therapeutic
monitoring and patient compliance for a complex botanical extract (eg, ATB) and reporting …