[HTML][HTML] Malaria vaccines: from the past towards the mRNA vaccine era

ME Tsoumani, C Voyiatzaki, A Efstathiou - Vaccines, 2023 - mdpi.com
Plasmodium spp. is the etiological agent of malaria, a life-threatening parasitic disease
transmitted by infected mosquitoes. Malaria remains a major global health challenge …

Antibodies against Plasmodium falciparum malaria at the molecular level

JP Julien, H Wardemann - Nature Reviews Immunology, 2019 - nature.com
Malaria is a vector-borne disease of global importance, with the vast majority of its life-
threatening cases caused by infection with Plasmodium falciparum parasites. Repeated …

[HTML][HTML] Five decades of clinical assessment of whole-sporozoite malaria vaccines

H Nunes-Cabaço, D Moita, M Prudêncio - Frontiers in Immunology, 2022 - frontiersin.org
In 1967, pioneering work by Ruth Nussenzweig demonstrated for the first time that irradiated
sporozoites of the rodent malaria parasite Plasmodium berghei protected mice against a …

[HTML][HTML] Plasmodium genomics: an approach for learning about and ending human malaria

JA Garrido-Cardenas, L González-Cerón… - Parasitology …, 2019 - Springer
Malaria causes high levels of morbidity and mortality in human beings worldwide. According
to the World Health Organization (WHO), about half a million people die of this disease each …

[HTML][HTML] Host-parasite interactions during Plasmodium infection: Implications for immunotherapies

P Chandley, R Ranjan, S Kumar, S Rohatgi - Frontiers in Immunology, 2023 - frontiersin.org
Malaria is a global infectious disease that remains a leading cause of morbidity and mortality
in the developing world. Multiple environmental and host and parasite factors govern the …

The PfAP2‐G2 transcription factor is a critical regulator of gametocyte maturation

S Singh, JM Santos, LM Orchard… - Molecular …, 2021 - Wiley Online Library
Differentiation from asexual blood stages to mature sexual gametocytes is required for the
transmission of malaria parasites. Here, we report that the ApiAP2 transcription factor, PfAP2 …

Antimalarial transmission-blocking interventions: past, present, and future

MJ Delves, F Angrisano, AM Blagborough - Trends in parasitology, 2018 - cell.com
Malaria remains a major global health challenge. Appropriate use of current antimalarial
tools has reduced the disease burden, but morbidity and mortality remain unacceptably …

Vaccines and monoclonal antibodies: new tools for malaria control

K Miura, Y Flores-Garcia, CA Long… - Clinical Microbiology …, 2024 - Am Soc Microbiol
Malaria remains one of the biggest health problems in the world. While significant reductions
in malaria morbidity and mortality had been achieved from 2000 to 2015, the favorable trend …

[HTML][HTML] Monoclonal antibodies for malaria prevention

M Aleshnick, M Florez-Cuadros, T Martinson… - Molecular Therapy, 2022 - cell.com
Monoclonal antibodies are highly specific proteins that are cloned from a single B cell and
bind to a single epitope on a pathogen. These laboratory-made molecules can serve as …

Vaccines against malaria—still a long way to go

K Matuschewski - The FEBS journal, 2017 - Wiley Online Library
Several species of Plasmodium cause a broad spectrum of human disease that range from
nausea and fever to severe anemia, cerebral malaria, and multiorgan failure. In malaria …