Transient receptor potential canonical (TRPC) channels constitute a group of receptor-
operated calcium-permeable nonselective cation channels of the TRP superfamily. The …

Cardiac fibroblasts (CF) play a pivotal role in preserving myocardial function and integrity of
the heart tissue after injury, but also contribute to future susceptibility to heart failure. CF …

Pulmonary arterial hypertension (PAH) is due to progressive distal pulmonary artery (PA)
obstruction, leading to right ventricular hypertrophy and failure. Exacerbated store-operated …

Store-operated Ca2+ entry (SOCE) is activated in response to the inositol-1, 4, 5-
trisphosphate (InsP3)-dependent depletion of the endoplasmic reticulum (ER) Ca2+ store …

Aldosterone's role in the kidney and its pathophysiologic actions in hypertension are well
known. However, its role or that of its receptor [minieralocorticoid receptor (MR)] in other …

Background Right ventricular (RV) function is the most important prognostic factor for
pulmonary arterial hypertension (PAH) patients. The progressive increase of pulmonary …

Cardiac, skeletal, and smooth muscle cells shared the common feature of contraction in
response to different stimuli. Agonist-induced muscle's contraction is triggered by a cytosolic …

Calcium is an important second messenger required not only for the excitation-contraction
coupling of the heart but also critical for the activation of cell signaling pathways involved in …

Background: Orai1 is a critical ion channel subunit, best recognized as a mediator of store-
operated Ca2+ entry (SOCE) in nonexcitable cells. SOCE has recently emerged as a key …

Transient receptor potential canonical (TRPC) proteins assemble to form homo-or
heterotetrameric, nonselective cation channels permeable to K+, Na+, and Ca2+. TRPC …