Smart Nanoscale Extracellular Vesicles in the Brain: Unveiling their Biology, Diagnostic Potential, and Therapeutic Applications

A Onkar, F Khan, A Goenka… - … Applied Materials & …, 2024 - ACS Publications
Information exchange is essential for the brain, where it communicates the physiological and
pathological signals to the periphery and vice versa. Extracellular vesicles (EVs) are a …

Preclinical animal models to evaluate therapeutic antiviral antibodies

A De Meyer, P Meuleman - Antiviral Research, 2024 - Elsevier
Despite the availability of effective preventative vaccines and potent small-molecule antiviral
drugs, effective non-toxic prophylactic and therapeutic measures are still lacking for many …

Cholesterol-Modified Anti-Il6 siRNA Reduces the Severity of Acute Lung Injury in Mice

IV Chernikov, IK Bachkova, AV Sen'kova… - Cells, 2024 - mdpi.com
Small interfering RNA (siRNA) holds significant therapeutic potential by silencing target
genes through RNA interference. Current clinical applications of siRNA have been primarily …

Titer and charge-based heterogeneity multiattribute monitoring of mAbs in cell culture harvest using 2D ProA CEX MS

D Sarin, S Kumar, AS Rathore - Talanta, 2024 - Elsevier
Robust monitoring of heterogeneity in biopharmaceutical development is crucial for
producing safe and efficacious biotherapeutic products. Multiattribute monitoring (MAM) has …

Current development of severe acute respiratory syndrome coronavirus 2 neutralizing antibodies

T Zhang, D Yang, L Tang, Y Hu - Molecular Medicine …, 2024 - spandidos-publications.com
The coronavirus disease 2019 pandemic due to severe acute respiratory syndrome
coronavirus 2 (SARS‑CoV‑2) seriously affected global public health security. Studies on …

[PDF][PDF] A Comprehensive Review of Monoclonal Antibodies in Modern Medicine: Tracing the Evolution of a Revolutionary Therapeutic Approach

M Kothari, A Wanjari, S Acharya, V Karwa, R Chavhan… - Cureus, 2024 - cureus.com
Monoclonal antibodies (mAbs) have emerged as potent therapeutic agents, revolutionizing
the landscape of modern medicine. This comprehensive review traces the evolution of mAbs …