Quinolines and isoquinolines as HIV-1 inhibitors: Chemical structures, action targets, and biological activities
S Hu, J Chen, JX Cao, SS Zhang, SX Gu, FE Chen - Bioorganic Chemistry, 2023 - Elsevier
Human immunodeficiency virus type 1 (HIV-1), a lentivirus that causes acquired
immunodeficiency syndrome (AIDS), poses a serious threat to global public health. Since …
immunodeficiency syndrome (AIDS), poses a serious threat to global public health. Since …
Medicinal Chemistry Perspectives on the Development of Piperazine-Containing HIV-1 Inhibitors
CA Salubi, HS Abbo, N Jahed, S Titinchi - Bioorganic & Medicinal …, 2024 - Elsevier
The Human immunodeficiency virus (HIV) is the causative agent of acquired
immunodeficiency syndrome (AIDS), one of the most perilous diseases known to …
immunodeficiency syndrome (AIDS), one of the most perilous diseases known to …
N-Phenyl-1-(phenylsulfonyl)-1H-1,2,4-triazol-3-amine as a New Class of HIV-1 Non-nucleoside Reverse Transcriptase Inhibitor
T Lane, V Makarov, JAE Nelson… - Journal of medicinal …, 2023 - ACS Publications
Highly active antiretroviral therapy (HAART) has revolutionized human immunodeficiency
virus (HIV) healthcare, turning it from a terminal to a potentially chronic disease, although …
virus (HIV) healthcare, turning it from a terminal to a potentially chronic disease, although …
Discovering potential inhibitors of the YEATS domain of YEATS2 through virtual screening, molecular optimization and molecular dynamics simulations
X Wang, G Cheng, J Zhao, P Gao, H Mao… - New Journal of …, 2023 - pubs.rsc.org
YEATS domains have been recently identified as novel readers of histone lysine acylation.
Increasing evidence has revealed that dysregulated interactions between YEATS domains …
Increasing evidence has revealed that dysregulated interactions between YEATS domains …
[HTML][HTML] Discovery of novel sulfonamide substituted indolylarylsulfones as potent HIV-1 inhibitors with better safety profiles
S Gao, L Song, Y Cheng, F Zhao, D Kang… - … Pharmaceutica Sinica B, 2023 - Elsevier
Indolylarylsulfones (IASs) are classical HIV-1 non-nucleoside reverse transcriptase
inhibitors (NNRTIs) with a unique scaffold and possess potent antiviral activity. To address …
inhibitors (NNRTIs) with a unique scaffold and possess potent antiviral activity. To address …
Identification of Ebselen derivatives as novel SARS-CoV-2 main protease inhibitors: Design, synthesis, biological evaluation, and structure-activity relationships …
H Zhang, J Li, K Toth, AE Tollefson, L Jing… - Bioorganic & Medicinal …, 2023 - Elsevier
The main protease (M pro) represents one of the most effective and attractive targets for
designing anti-SARS-CoV-2 drugs. In this study, we designed and synthesized a novel …
designing anti-SARS-CoV-2 drugs. In this study, we designed and synthesized a novel …