Since December 2019, the world has been experiencing the challenge of facing coronavirus
disease-19 (COVID-19), a severe infectious disease caused by the new coronavirus, SARS …

Late-life depression occurring in older adults is common, recurrent, and malignant. It is
characterized by affective symptoms, but also cognitive decline, medical comorbidity, and …

The function and regulation of different heterogeneous reactive states of astrocytes in
depression remain unclear. Here, we demonstrate that neurotoxic reactive (A1-like) …

Previous studies have documented the protective effects of social participation on
depression in older adults. In this study, we investigated the association between social …

Importance Late-life depression (LLD) is characterized by considerable heterogeneity in
clinical manifestation. Unraveling such heterogeneity might aid in elucidating etiological …

Depression and dementia are major public health problems. Major depressive disorder
(MDD) and Alzheimer's disease (AD) reciprocally elevate the risk for one another. No …

Subclinical depressive symptoms are associated with increased risk of Alzheimer's disease
(AD), but the brain mechanisms underlying this relationship are still unclear. We aimed to …

Late-life depression is associated with significant cognitive impairment. Meta-analyses
showed that depression is associated with an increased risk for Alzheimer's disease (AD) …

This narrative review aimed to explore the existing knowledge in order to examine the
multiple forms of late-life depression (LLD) within a non-neurodegenerative or a …

Multimorbidity and depression are complex multifactorial conditions with major implications
for older individuals, their families, and healthcare providers. In this scoping review, we …