From nature to industry: Harnessing enzymes for biocatalysis

R Buller, S Lutz, RJ Kazlauskas, R Snajdrova… - Science, 2023 - science.org
Biocatalysis harnesses enzymes to make valuable products. This green technology is used
in countless applications from bench scale to industrial production and allows practitioners …

Pathogenesis of celiac disease and other gluten related disorders in wheat and strategies for mitigating them

N Sharma, S Bhatia, V Chunduri, S Kaur… - Frontiers in …, 2020 - frontiersin.org
Wheat is a major cereal crop providing energy and nutrients to the billions of people around
the world. Gluten is a structural protein in wheat, that is necessary for its dough making …

The Rosetta all-atom energy function for macromolecular modeling and design

RF Alford, A Leaver-Fay, JR Jeliazkov… - Journal of chemical …, 2017 - ACS Publications
Over the past decade, the Rosetta biomolecular modeling suite has informed diverse
biological questions and engineering challenges ranging from interpretation of low …

Current and emerging therapies for coeliac disease

L Kivelä, A Caminero, DA Leffler… - Nature reviews …, 2021 - nature.com
Coeliac disease is a common enteropathy that occurs in genetically susceptible individuals
in response to the ingestion of gluten proteins present in wheat, rye and barley. Currently …

Enzyme engineering: Reshaping the biocatalytic functions

M Ali, HM Ishqi, Q Husain - Biotechnology and bioengineering, 2020 - Wiley Online Library
Enzyme engineering is a powerful tool to fine‐tune the enzymes. It is a technique by which
the stability, activity, and specificity of the enzymes can be altered. The characteristic …

[HTML][HTML] Evaluating responses to gluten challenge: a randomized, double-blind, 2-dose gluten challenge trial

MM Leonard, JA Silvester, D Leffler, A Fasano… - Gastroenterology, 2021 - Elsevier
Background & Aims Gluten challenge is used to diagnose celiac disease (CeD) and for
clinical research. Sustained gluten exposure reliably induces histologic changes but is …

Gluten degrading enzymes for treatment of celiac disease

G Wei, EJ Helmerhorst, G Darwish, G Blumenkranz… - Nutrients, 2020 - mdpi.com
Celiac disease (CeD) affects about 1% of most world populations. It presents a wide
spectrum of clinical manifestations, ranging from minor symptoms to mild or severe …

New Developments in celiac disease treatment

MV Machado - International journal of molecular sciences, 2023 - mdpi.com
Celiac disease (CD) is a common autoimmune disease affecting around 1% of the
population. It consists of an immune-mediated enteropathy, triggered by gluten exposure in …

Evolving therapy for celiac disease

S Yoosuf, GK Makharia - Frontiers in pediatrics, 2019 - frontiersin.org
Gluten is known to be the main triggering factor for celiac disease (CeD), an immune-
mediated disorder. CeD is therefore managed using a strict and lifelong gluten-free diet …

Celiac disease: mechanisms and emerging therapeutics

HA Besser, C Khosla - Trends in Pharmacological Sciences, 2023 - cell.com
Celiac disease (CeD) is a widespread, gluten-induced, autoimmune disorder that lacks any
medicinal therapy. Towards the goal of developing non-dietary treatments for CeD, research …