The innate immune system constitutes the first line of defense against invading microbial
pathogens and relies on a large family of pattern recognition receptors (PRRs), which detect …

The airway epithelium acts as a frontline defense against respiratory viruses, not only as a
physical barrier and through the mucociliary apparatus but also through its immunological …

Coatomer complex I (COPI) mediates retrograde vesicular trafficking from Golgi to the
endoplasmic reticulum (ER) and within Golgi compartments. Deficiency in subunit alpha …

The interferon (IFN) system is an extremely powerful antiviral response that is capable of
controlling most, if not all, virus infections in the absence of adaptive immunity. However …

Interferons (IFN) exert antiviral, immunomodulatory and cytostatic activities. IFN-α/β (type I
IFN) and IFN-λ (type III IFN) bind distinct receptors, but regulate similar sets of genes and …

Interferons (IFNs) can serve as the first line of immune defense against viral infection. The
identification of IFN-λs 1, 2, 3 & 4 (termed as type III IFNs) has revealed that the antiviral …

The human myxovirus resistance protein 1 (MxA) is a key mediator of the interferon-induced
antiviral response against a wide range of viruses. MxA expression is tightly regulated by …

Virus-infected cells secrete a broad range of interferon (IFN) subtypes which in turn trigger
the synthesis of antiviral factors that confer host resistance. IFN-α, IFN-β and other type I …

A significant body of data implicates the type I interferon (IFN) pathway in the pathogenesis
of autoimmune rheumatic diseases. In these disorders, a self-reinforcing cycle of IFN …

Objectives To investigate the role of miR-146a in dengue virus (DENV) replication. Methods
Expression levels of miR-146a were measured by real-time PCR and Northern blot. Role of …