Insulin-like growth factor-1 (IGF-1) is a key growth factor that regulates both anabolic and
catabolic pathways in skeletal muscle. IGF-1 increases skeletal muscle protein synthesis via …

By 2050, the American 85 years old and over population will triple. Clinicians and the public
health community need to develop a culture of sensitivity to the needs of this population and …

Evidence suggests that gut microbiota composition and diversity can be a determinant of
skeletal muscle metabolism and functionality. This is true in catabolic (sarcopenia and …

Age‐associated diseases are rising to pandemic proportions, exposing the need for efficient
and low‐cost methods to tackle these maladies at symptomatic, behavioral, metabolic, and …

Background loneliness and social isolation have been associated with mortality and with
functional decline in older people. We investigated whether loneliness or social isolation are …

During aging and menopausal transition in women, a progressive muscle degeneration (ie
decrease in quality and muscle function) occurs. This muscle dysfunction, caused by …

Frailty and sarcopenia are important concepts in the quest to prevent physical dependence,
as geriatrics are shifting towards identifications of early stages of disability. Definitions of …

Maintenance of skeletal muscle mass is regulated by the balance between anabolic and
catabolic processes. Mammalian target of rapamycin (mTOR) is an evolutionarily conserved …

Sarcopenia is defined as an age associated decline in skeletal muscle mass. The
pathophysiology of sarcopenia is multifactorial, with decreased caloric intake, muscle fiber …

The first reports of accurate skeletal muscle mass measurement in human subjects
appeared at about the same time as introduction of the sarcopenia concept in the late …