Chronic kidney disease (CKD) is an inherently systemic disease that refers to a long-term
loss of kidney function. The progression of CKD has repercussions for other organs, leading …

The causes of excess cardiovascular mortality associated with chronic kidney disease
(CKD) have been attributed in part to the CKD-mineral bone disorder syndrome (CKD-MBD) …

In addition to its structural role, the skeleton serves as an endocrine organ that controls
mineral metabolism and energy homeostasis. Three major cell types in bone-osteoblasts …

Chronic kidney disease (CKD) is known to involve inflammation, oxidative stress and
apoptosis. Here, we investigated the impact of curcumin (diferuloyl methane, a phenolic …

Osteoblast differentiation is predominantly regulated by the WNT/β-catenin signaling
(canonical WNT pathway), which, together with bone morphogenetic proteins, acts as the …

Ageing increases susceptibility to neurodegenerative disorders, such as Alzheimer's
disease (AD). Serum levels of sclerostin, an osteocyte-derived Wnt–β-catenin signalling …

Background Osteoprotegerin (OPG), sclerostin and DKK1 constitute opposite bone turnover
inhibitors, OPG inhibiting osteoclastogenesis while sclerostin and DKK1 exerting their …

For more than a decade, the Wnt–β-catenin pathway has been the focus of intense basic
and clinical research in the bone field because of its importance in skeletal development …

Biochemical markers of bone turnover have been used for decades in the management of
bone diseases, to assess the prognosis of these conditions and to monitor treatments. The …

Context: Sclerostin serum levels are increased in patients with chronic kidney disease
(CKD). Osteoporosis and CKD often occur simultaneously. Currently antisclerostin …