[HTML][HTML] Cellular metabolism: a fundamental component of degeneration in the nervous system

K Maiese - Biomolecules, 2023 - mdpi.com
It is estimated that, at minimum, 500 million individuals suffer from cellular metabolic
dysfunction, such as diabetes mellitus (DM), throughout the world. Even more concerning is …

[HTML][HTML] Irisin: an anti-inflammatory exerkine in aging and redox-mediated comorbidities

CS Trettel, BRA Pelozin, MP Barros… - Frontiers in …, 2023 - frontiersin.org
Human beings lead largely sedentary lives. From an evolutionary perspective, such lifestyle
is not beneficial to health. Exercise can promote many enabling pathways, particularly …

[HTML][HTML] The metabolic basis for nervous system dysfunction in alzheimer's disease, parkinson's disease, and huntington's disease

K Maiese - Current neurovascular research, 2023 - ncbi.nlm.nih.gov
Disorders of metabolism affect multiple systems throughout the body, but may have the
greatest impact on both central and peripheral nervous systems. Current available …

Mechanistic insights into the beneficial effects of curcumin on insulin resistance: opportunities and challenges

P Balakumar, K Venkatesan, NA Khan… - Drug discovery today, 2023 - Elsevier
The past couple of decades in particular have seen a rapid increase in the prevalence of
type 2 diabetes mellitus (T2DM), a debilitating metabolic disorder characterised by insulin …

Apolipoprotein-4 allele (APOE-4) as a Mediator of Cognitive Loss and Dementia in Long COVID-19

K Maiese - Current Neurovascular Research, 2022 - ingentaconnect.com
The sporadic form of Alzheimer's disease (AD) represents most of the clinical cases for AD
and at least ten percent of the global population over the age of 65 are affected by sporadic …

Ferroptosis, iron metabolism, and forkhead transcription factors (Foxos)

K Maiese - Current Neurovascular Research, 2023 - ingentaconnect.com
Iron metabolism in the body is a critical process for sustaining life as well as determining cell
fate [1-4]. As an essential element, iron in the ferrous state (Fe2+) is an electron donor but in …

[HTML][HTML] The impact of aging and oxidative stress in metabolic and nervous system disorders: programmed cell death and molecular signal transduction crosstalk

K Maiese - Frontiers in Immunology, 2023 - frontiersin.org
Life expectancy is increasing throughout the world and coincides with a rise in non-
communicable diseases (NCDs), especially for metabolic disease that includes diabetes …

[HTML][HTML] Innovative therapeutic strategies for cardiovascular disease

K Maiese - EXCLI journal, 2023 - ncbi.nlm.nih.gov
As a significant non-communicable disease, cardiovascular disease is the leading cause of
death for both men and women, comprises almost twenty percent of deaths in most racial …

[HTML][HTML] Cognitive impairment in multiple sclerosis

K Maiese - Bioengineering, 2023 - mdpi.com
Almost three million individuals suffer from multiple sclerosis (MS) throughout the world, a
demyelinating disease in the nervous system with increased prevalence over the last five …

[HTML][HTML] Physical Activity Modifies the Severity of COVID-19 in Hospitalized Patients—Observational Study

E Sutkowska, A Stanek, K Madziarska… - Journal of Clinical …, 2023 - mdpi.com
Background and aim: Physical activity (PA) can modulate the immune response, but its
impact on infectious disease severity is unknown. We assess if the PA level impacts the …