Degradable controlled-release polymers and polymeric nanoparticles: mechanisms of controlling drug release

N Kamaly, B Yameen, J Wu, OC Farokhzad - Chemical reviews, 2016 - ACS Publications
The development of biodegradable polymers represents a revolution in medicine spanning
over 50 years and leading to significant biotechnological advancements in drug delivery …

Surface functionalization and targeting strategies of liposomes in solid tumor therapy: A review

MK Riaz, MA Riaz, X Zhang, C Lin, KH Wong… - International journal of …, 2018 - mdpi.com
Surface functionalization of liposomes can play a key role in overcoming the current
limitations of nanocarriers to treat solid tumors, ie, biological barriers and physiological …

siRNA versus miRNA as therapeutics for gene silencing

JKW Lam, MYT Chow, Y Zhang, SWS Leung - Molecular Therapy-Nucleic …, 2015 - cell.com
Discovered a little over two decades ago, small interfering RNAs (siRNAs) and microRNAs
(miRNAs) are noncoding RNAs with important roles in gene regulation. They have recently …

Lipid-based nanoparticle formulations for small molecules and RNA drugs

LM Ickenstein, P Garidel - Expert opinion on drug delivery, 2019 - Taylor & Francis
Introduction: Liposomes and lipid-based nanoparticles (LNPs) effectively deliver cargo
molecules to specific tissues, cells, and cellular compartments. Patients benefit from these …

Multi‐stimuli‐responsive polymer materials: Particles, films, and bulk gels

ZQ Cao, GJ Wang - The Chemical Record, 2016 - Wiley Online Library
Stimuli‐responsive polymers have received tremendous attention from scientists and
engineers for several decades due to the wide applications of these smart materials in …

Updates on the use of liposomes for active tumor targeting in cancer therapy

W Yan, SSY Leung, KKW To - Nanomedicine, 2020 - Taylor & Francis
In the development of cancer chemotherapy, besides the discovery of new anticancer drugs,
a variety of nanocarrier systems for the delivery of previously developed and new …

A review on cationic lipids with different linkers for gene delivery

D Zhi, Y Bai, J Yang, S Cui, Y Zhao, H Chen… - Advances in colloid and …, 2018 - Elsevier
Cationic lipids have become known as one of the most versatile tools for the delivery of
DNA, RNA and many other therapeutic molecules, and are especially attractive because …

Enzyme-responsive liposomes for the delivery of anticancer drugs

F Fouladi, KJ Steffen, S Mallik - Bioconjugate Chemistry, 2017 - ACS Publications
Liposomes are nanocarriers that deliver the payloads at the target site, leading to
therapeutic drug concentrations at the diseased site and reduced toxic effects in healthy …

[HTML][HTML] Microbubbles and nanobubbles with ultrasound for systemic gene delivery

Y Endo-Takahashi, Y Negishi - Pharmaceutics, 2020 - mdpi.com
The regulation of gene expression is a promising therapeutic approach for many intractable
diseases. However, its use in clinical applications requires the efficient delivery of nucleic …

Drug nanocrystallisation within liposomes

T Li, D Cipolla, T Rades, BJ Boyd - Journal of Controlled Release, 2018 - Elsevier
Liposomes are phospholipid bilayer vesicles that have been explored in pharmaceutical
research as drug delivery systems for> 50 years. Despite being important to their …