Brain organoids: A revolutionary tool for modeling neurological disorders and development of therapeutics

P Acharya, NY Choi, S Shrestha… - Biotechnology and …, 2024 - Wiley Online Library
Brain organoids are self‐organized, three‐dimensional (3D) aggregates derived from
pluripotent stem cells that have cell types and cellular architectures resembling those of the …

[HTML][HTML] Isolation, Identification, Activity Evaluation, and Mechanism of Action of Neuroprotective Peptides from Walnuts: A Review

L Zhang, YY Bai, ZS Hong, J Xie, Y Tian - Nutrients, 2023 - mdpi.com
As human life expectancy increases, the incidence of neurodegenerative diseases in older
adults has increased in parallel. Walnuts contain bioactive peptides with demonstrated …

[HTML][HTML] Ginkgo biloba: A Leaf of Hope in the Fight against Alzheimer's Dementia: Clinical Trial Systematic Review

GLO Pagotto, LMO Santos, N Osman, CB Lamas… - Antioxidants, 2024 - mdpi.com
Alzheimer's disease (AD) is a stealthy and progressive neurological disorder that is a
leading cause of dementia in the global elderly population, imposing a significant burden on …

Macrophage-mediated controlled release of cysteine protease inhibitor from PLGA-PEG/hydroxyapatite microspheres for targeting cathepsin S in Alzheimer's disease

IH Yang, CY Kuan, SL Zhang, ZY Chen, CH Li… - European Polymer …, 2024 - Elsevier
The cause of Alzheimer's disease (AD) remains unknown; however, studies have indicated
the increased expression of cathepsin S (CTSS) in AD brains. Cathepsin S acts as a β …

[HTML][HTML] Insights on the Use of Transgenic Mice Models in Alzheimer's Disease Research

MS Pádua, JL Guil-Guerrero, JAM Prates… - International Journal of …, 2024 - mdpi.com
Alzheimer's disease (AD), the leading cause of dementia, presents a significant global
health challenge with no known cure to date. Central to our understanding of AD …

[HTML][HTML] Dynamic culture of cerebral organoids using a pillar/perfusion plate for the assessment of developmental neurotoxicity

P Acharya, S Shrestha, P Joshi, NY Choi, VKR Lekkala… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Despite the potential toxicity of commercial chemicals to the development of the nervous
system (known as developmental neurotoxicity or DNT), conventional in vitro cell models …

Development of a high-throughput, quantitative platform using human cerebral organoids to study virus-induced neuroinflammation in Alzheimer's disease

MN Olson, P Dawes, LF Murray, NJ Barton… - bioRxiv, 2024 - biorxiv.org
Neuroinflammation is a central process in the pathogenesis of several neurodegenerative
diseases such as Alzheimer's disease (AD), and there are active efforts to target pathways …

[图书][B] Neurodegeneración y alzhéimer: Avances tecnológicos y de investigación para la prevención y el tratamiento

AN Cuartiellas, NG Fombuena - 2024 - books.google.com
Las enfermedades neurodegenerativas son un desafío para la investigación porque la
mayoría afecta al cerebro, el órgano más complejo del cuerpo humano. El alzhéimer es la …

Étude in vitro des effets neurotoxiques et neuro-inflammatoires de trois toxiques environnementaux analogues d'acides aminés sur des modèles de culture de cellules …

S Méresse - 2023 - theses.hal.science
Les polluants environnementaux, comme le glyphosate (GLY) et le glufosinate d'ammonium
(GLA) sont des herbicides qui participent à l'eutrophisation des milieux. Cela conduit, en …