The main limitation to the success of central nervous system (CNS) therapies lies in the
difficulty for drugs to cross the blood–brain barrier (BBB) and reach the brain. Regarding its …

Despite the increasing global incidence of brain disorders, achieving sufficient delivery
towards the central nervous system (CNS) remains a formidable challenge in terms of …

Powders for nasal delivery have been recognized as advantageous dosage forms over
liquids due to increased stability and residence time on nasal mucosa, with improved …

Intranasal drug delivery is as a noninvasive and efficient approach extensively utilized for
treating the local, central nervous system, and systemic diseases. Despite numerous …

The clinical translation of stem cells and their extracellular vesicles (EVs)-based therapy for
central nervous system (CNS) diseases is booming. Nevertheless, the insufficient CNS …

Nasal drug delivery has been utilized for locally acting diseases for decades. The nose is
also a portal to the systemic circulation and central nervous system (CNS). In the age of …

Bioavailability assessment in the development phase of a drug product is vital to reveal the
disadvantageous properties of the substance and the possible technological interventions …

This review aims to cement three hot topics in drug delivery:(a) the pre-formulation of new
products intended for nose-to-brain delivery;(b) the development of nasal casts for studying …

The nasal route has been investigated as a promising alternative for drug delivery to the
central nervous system, avoiding passage through the blood–brain barrier and improving …

Abstract Crossing the Blood Brain Barrier constitutes a challenge in drug administration to
the brain. In this context, nose-to-brain delivery is explored as an alternative route in the …