Interferon (IFN)-mediated antiviral responses are central to host defence against viral
infection. Despite the existence of at least 20 IFNs, there are only three known cell surface …

Type I interferons (IFNs) have diverse effects on innate and adaptive immune cells during
infection with viruses, bacteria, parasites and fungi, directly and/or indirectly through the …

Interferon (IFN)-I and IFN-II both induce IFN-stimulated gene (ISG) expression through Janus
kinase (JAK)-dependent phosphorylation of signal transducer and activator of transcription …

When type III interferon (IFN-λ; also known as interleukin-28 [IL-28] and IL-29) was
discovered in 2003, its antiviral function was expected to be analogous to that of type I IFNs …

Interferons (IFNs) can serve as the first line of immune defense against viral infection. The
identification of IFN-λs 1, 2, 3 & 4 (termed as type III IFNs) has revealed that the antiviral …

В монографии приведены сведения по роли цитокинов в регуляции физиологических
процессов, защитных реакций организма и в патогенезе иммунопатологических …

Although interferon-λ [also known as type III interferon or interleukin-28 (IL-28)/IL-29]
restricts infection by several viruses, its inhibitory mechanism has remained uncertain. We …

If there is a great new hope in the treatment of cancer, the immune system is it. Innate and
adaptive immunity either promote or attenuate tumorigenesis and so can have opposing …

Interferon (IFN) responses, mediated by a myriad of IFN-stimulated genes (ISGs), are the
most profound innate immune responses against viruses. Cumulatively, these IFN effectors …

Much progress has been made in the identification of specific human gene variants that
contribute to enhanced susceptibility or resistance to viral diseases. Herein we review …