Drug–drug interactions (DDIs) caused by the co‐administration of multiple drugs are major
safety concerns in the clinic. Several drugs have been withdrawn from the market due to …

Accurate prediction of human clearance (CL) and volume of distribution at steady state (Vd,
ss) for small molecule drug candidates is an essential component of assessing likely …

The humanization of animals is a powerful tool for the exploration of human disease
pathogenesis in biomedical research, as well as for the development of therapeutic …

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Quantitative systems pharmacology holds the promises of integrating results from laboratory
animals or in vitro human systems into the design of human pharmacokinetic …

Paclobutrazol (PBZ) is a plant growth regulator that can delay plant growth and improve
plant resistance and yield. Although it has been widely used in the growth of medicinal …

We previously reported a prediction method for human pharmacokinetics (PK) using single
species allometric scaling (SSS) and the complex Dedrick plot in chimeric mice with …

The ability to predict human liver-to-plasma unbound partition coefficient (Kpuu) is important
to estimate unbound liver concentration for drugs that are substrates of hepatic organic …

Benzbromarone, a uricosuric drug, has the potential to cause serious hepatotoxicity. Several
studies have shown the formation of reactive metabolites of benzbromarone and their …

E0703, a new steroidal compound optimized from estradiol, significantly increased cell
proliferation and the survival rate of KM mice and beagles after ionizing radiation. In this …