Nucleic acid therapy can achieve lasting and even curative effects through gene
augmentation, gene suppression, and genome editing. However, it is difficult for naked …

The field of gene therapy has experienced an insurgence of attention for its widespread
ability to regulate gene expression by targeting genomic DNA, messenger RNA, microRNA …

Non-viral vehicles hold therapeutic promise in advancing the delivery of a variety of cargos
in vitro and in vivo, including small molecule drugs, biologics, and especially nucleic acids …

Multiple extra-and intracellular obstacles, including low stability in blood, poor cellular
uptake, and inefficient endosomal escape and disassembly in the cytoplasm, have to be …

Nano-drug/gene delivery systems (DDS) are powerful weapons for the targeted delivery of
various therapeutic molecules in treatment of tumors. Nano systems are being extensively …

Micelles have demonstrated an excellent ability to deliver several different types of
therapeutic agents, including chemotherapy drugs, proteins, small‐interfering RNA and …

Despite the extracellular barriers for siRNA delivery have been overcome by utilizing
advanced nanoparticle delivery systems, the key intracellular barriers after internalization …

Dendrimer, such as dendrigraft poly-L-lysine (DGL) polymers, with high surface charge
density, well-defined structure, and narrow poly-dispersity is often employed as a gene …

Silencing the expression of a target gene by RNA interference (RNAi) shows promise as a
potentially revolutionizing strategy for manipulating biological (pathological) pathways at the …

Advancements in nanotechnology have resulted in the introduction of several nonviral
delivery vectors for the nontoxic, efficient delivery of encapsulated mRNA-based vaccines …