Artificial intelligence and corneal confocal microscopy: the start of a beautiful relationship

U Alam, M Anson, Y Meng, F Preston, V Kirthi… - Journal of Clinical …, 2022 - mdpi.com
Corneal confocal microscopy (CCM) is a rapid non-invasive in vivo ophthalmic imaging
technique that images the cornea. Historically, it was utilised in the diagnosis and clinical …

Corneal confocal microscopy to image small nerve fiber degeneration: ophthalmology meets neurology

IN Petropoulos, G Bitirgen, M Ferdousi… - Frontiers in Pain …, 2021 - frontiersin.org
Neuropathic pain has multiple etiologies, but a major feature is small fiber dysfunction or
damage. Corneal confocal microscopy (CCM) is a rapid non-invasive ophthalmic imaging …

In-vivo corneal confocal microscopy: Imaging analysis, biological insights and future directions

JCB Chiang, M Roy, J Kim, M Markoulli… - Communications …, 2023 - nature.com
In-vivo corneal confocal microscopy is a powerful imaging technique which provides
clinicians and researcher with the capabilities to observe microstructures at the ocular …

Impact of chronic kidney disease on corneal neuroimmune features in type 2 diabetes

K Asiedu, M Markoulli, SS Tummanapalli… - Journal of Clinical …, 2022 - mdpi.com
Aim: To determine the impact of chronic kidney disease on corneal nerve measures and
dendritic cell counts in type 2 diabetes. Methods: In vivo corneal confocal microscopy …

Small fiber neuropathy for assessment of disease severity in amyotrophic lateral sclerosis: corneal confocal microscopy findings

J Fu, J He, Y Zhang, Z Liu, H Wang, J Li, L Chen… - Orphanet Journal of …, 2022 - Springer
Background Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder with
progressive motor system impairment, and recent evidence has identified the extra-motor …

Corneal confocal microscopy to detect early immune‐mediated small nerve fibre loss in AL amyloidosis

A Thimm, A Carpinteiro, S Oubari… - Annals of Clinical …, 2022 - Wiley Online Library
Objective Light chain (AL) amyloidosis is a life‐threatening disorder characterised by
extracellular deposition of amyloid leading to dysfunction of multiple organs. Peripheral …

Corneal confocal microscopy reveals small nerve fibre loss correlating with motor function in adult spinal muscular atrophy

A Thimm, S Brakemeier, M Dag… - European Journal of …, 2023 - Wiley Online Library
Background 5q Spinal muscular atrophy (SMA) is a progressive, inherited, and severely
disabling–yet treatable–motor neuron disease. Although treatment options have evolved in …

The functional and structural evaluation of small fibers in asymptomatic carriers of TTR p. Val50Met (Val30Met) mutation

CE Bekircan-Kurt, E Yilmaz, D Arslan, FG Yildiz… - Neuromuscular …, 2022 - Elsevier
Therapeutic advances in hereditary amyloid transthyretin (ATTRv) amyloidosis with
polyneuropathy extended life expectancy and delayed symptom progression especially in …

Corneal confocal microscopy identifies corneal nerve loss and increased Langerhans cells in presymptomatic carriers and patients with hereditary transthyretin …

A Thimm, A Carpinteiro, S Oubari, M Papathanasiou… - Journal of …, 2023 - Springer
Abstract Background Hereditary transthyretin amyloidosis (ATTRv amyloidosis) is a rare, but
life-threatening protein misfolding disorder due to TTR gene mutations. Cardiomyopathy …

Reproducibility and reliability of subbasal corneal nerve parameters of the inferior whorl in the neurotoxic and healthy cornea

JCB Chiang, V Khou, A Tavakoli, SB Park, D Goldstein… - Cornea, 2022 - journals.lww.com
Purpose: The aim of this study was to investigate the reliability of subbasal corneal nerve
plexus parameters of the inferior whorl compared with the central cornea with in vivo corneal …