Alzheimer's disease (AD) is the most common type of neurodegenerative disease. Its typical
pathology consists of extracellular amyloid-β (Aβ) plaques and intracellular tau …

B-cell-specific Moloney murine leukemia virus integration region 1 (Bmi-1, also known as
RNF51 or PCGF4) is one of the important members of the PcG gene family, and is involved …

Human cells are exposed to numerous exogenous and endogenous insults every day.
Unlike other molecules, DNA cannot be replaced by resynthesis, hence damage to DNA can …

Research in the last decade has clearly revealed a critical role of prostate cancer stem cells
(PCSCs) in prostate cancer (PC). Prostate stem cells (PSCs) reside in both basal and …

PD1 blockade-based combination therapy has been approved as a first-line treatment for
head and neck squamous cell carcinoma (HNSCC). However, the response rate remains …

Histone ubiquitination is a critical epigenetic mechanism regulating DNA-driven processes
such as gene transcription and DNA damage repair. Importantly, the cellular machinery …

Overproduction of pro‑inflammatory cytokines in the aged, which is called inflammaging,
leads to the deterioration of periodontitis. Toll‑like receptor 4 (TLR4) plays a role in the …

The PRC2 and PRC1 complexes are aberrantly expressed in human cancers and have
been linked to decreases in patient survival. MUC1-C is an oncoprotein that is also …

The assessment of the risk of biochemical recurrence (BCR) is critical in the management of
males with prostate cancer (PC). Over the past decades, a comprehensive effort has been …

The B-lymphoma Moloney murine leukemia virus insertion region-1 protein (BMI1) acts as
an oncogene in various cancers, including breast cancer. Recent evidence suggests that …