Despite being the most frequently altered oncogenic protein in solid tumours, KRAS has
historically been considered 'undruggable'owing to a lack of pharmacologically targetable …

Neutrophils are the most abundant myeloid cells in human blood and are emerging as
important regulators of cancer. However, their functional importance has often been …

Pancreatic cancer is an increasingly common cause of cancer mortality with a tight
correspondence between disease mortality and incidence. Furthermore, it is usually …

Tumor vascularization occurs through several distinct biological processes, which not only
vary between tumor type and anatomic location, but also occur simultaneously within the …

Pancreatic ductal adenocarcinoma (PDAC), which constitutes 90% of pancreatic cancers, is
the fourth leading cause of cancer-related deaths in the world. Due to the broad …

The chemokine receptors CXCR1/2 and their ligand CXCL8 are essential for the activation
and trafficking of inflammatory mediators as well as tumor progression and metastasis. The …

Pancreatic ductal adenocarcinoma carries a dismal prognosis, and outcomes have
improved little with modern therapeutics. Checkpoint-based immunotherapy has failed to …

Distinct tumor microenvironment forms in each progression step of cancer and has diverse
capacities to induce both adverse and beneficial consequences for tumorigenesis. It is now …

CXCR2 has been suggested to have both tumor-promoting and tumor-suppressive
properties. Here we show that CXCR2 signaling is upregulated in human pancreatic cancer …

Pancreatic ductal adenocarcinoma (PDAC) is known for its resistance to gemcitabine, which
acts to inhibit cell growth by termination of DNA replication. Tumor-associated macrophages …