A perspective study of the possible impact of obeticholic acid against SARS-CoV-2 infection

GES Batiha, HM Al-Kuraishy, AI Al-Gareeb… - …, 2023 - Springer
The causative agent of CoV disease 2019 is a new coronavirus CoV type 2, affecting the
respiratory tract with severe manifestations (SARS-CoV-2). Covid-19 is mainly symptomless …

Multi-omics and artificial intelligence-guided drug repositioning: prospects, challenges, and lessons learned from COVID-19

Y Cong, T Endo - OMICS: A Journal of Integrative Biology, 2022 - liebertpub.com
Drug repurposing is of interest for therapeutics innovation in many human diseases
including coronavirus disease 2019 (COVID-19). Methodological innovations in drug …

Drug repurposing for coronavirus (SARS-CoV-2) based on gene co-expression network analysis

H MotieGhader, E Safavi, A Rezapour, FF Amoodizaj… - Scientific reports, 2021 - nature.com
Severe acute respiratory syndrome (SARS) is a highly contagious viral respiratory illness.
This illness is spurred on by a coronavirus known as SARS-associated coronavirus (SARS …

Navigating with chemometrics and machine learning in chemistry

PB Joshi - Artificial Intelligence Review, 2023 - Springer
Chemometrics and machine learning are artificial intelligence-based methods stirring a
transformative change in chemistry. Organic synthesis, drug discovery and analytical …

[HTML][HTML] Machine learning for drug repositioning: Recent advances and challenges

L Cai, J Chu, J Xu, Y Meng, C Lu, X Tang… - Current Research in …, 2023 - Elsevier
Because translating the growing body of knowledge about human disease into treatments
has been slower than expected, the application of machine learning techniques to drug …

Repositioned Natural Compounds and Nanoformulations: A Promising Combination to Counteract Cell Damage and Inflammation in Respiratory Viral Infections

A Mariano, I Bigioni, M Marchetti, A Scotto d'Abusco… - Molecules, 2023 - mdpi.com
Respiratory viral diseases are among the most important causes of disability, morbidity, and
death worldwide. Due to the limited efficacy or side effects of many current therapies and the …

Alveolar regeneration in COVID-19 patients: a network perspective

SK Gupta, M Srivastava, R Minocha, A Akash… - International Journal of …, 2021 - mdpi.com
A viral infection involves entry and replication of viral nucleic acid in a host organism,
subsequently leading to biochemical and structural alterations in the host cell. In the case of …

Drug Repurposing for Newly Emerged Diseases via Network‐based Inference on a Gene‐disease‐drug Network

L Qin, J Wang, Z Wu, W Li, G Liu… - Molecular …, 2022 - Wiley Online Library
Identification of disease‐drug associations is an effective strategy for drug repurposing,
especially in searching old drugs for newly emerged diseases like COVID‐19. In this study …

Correlation-based network integration of lung RNA sequencing and DNA methylation data in chronic obstructive pulmonary disease

P Sibilio, F Conte, Y Huang, PJ Castaldi, CP Hersh… - Heliyon, 2024 - cell.com
Abstract Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous, chronic
inflammatory process of the lungs and, like other complex diseases, is caused by both …

Repurposing naproxen as a potential nucleocapsid antagonist of beta-coronaviruses: targeting a conserved protein in the search for a broad-spectrum treatment …

R Valadan, R Alizadeh-Navaei, M Lagzian… - Journal of …, 2024 - Taylor & Francis
Ongoing mutations in the coronavirus family, especially beta-coronaviruses, raise new
concerns about the possibility of new unexpected outbreaks. Therefore, it is crucial to …