Biomarker-driven development of new therapies for autoimmune diseases: current status and future promises

L Laigle, L Chadli, P Moingeon - Expert Review of Clinical …, 2023 - Taylor & Francis
Introduction Auto-immune diseases are complex and heterogeneous. Various types of
biomarkers can be used to support precision medicine approaches to autoimmune …

[HTML][HTML] Advanced in vitro models for renal cell carcinoma therapy design

V Mieville, AW Griffioen, D Benamran… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Renal cell carcinoma (RCC) and its principal subtype, clear cell RCC, are the most
diagnosed kidney cancer. Despite substantial improvement over the last decades, current …

Patient-derived mini-colons enable long-term modeling of tumor–microenvironment complexity

LF Lorenzo-Martín, N Broguiere, J Langer… - Nature …, 2024 - nature.com
Existing organoid models fall short of fully capturing the complexity of cancer because they
lack sufficient multicellular diversity, tissue-level organization, biological durability and …

Personalized medicine—Where do we stand regarding bench to bedside translation?

HRB Raghavendran, G Kumaramanickavel… - Frontiers in …, 2023 - frontiersin.org
Personalized medicine is a cutting-edge subspecialty of medicine. The American Cancer
Society states that “Precision medicine is a way for healthcare professionals to offer and …

Recommendations for robust and reproducible preclinical research in personalised medicine

V Fosse, E Oldoni, F Bietrix, A Budillon… - BMC medicine, 2023 - Springer
Background Personalised medicine is a medical model that aims to provide tailor-made
prevention and treatment strategies for defined groups of individuals. The concept brings …

Supporting evidence in phase 2 cancer trial protocols: A content analysis

S Bicer - 2024 - escholarship.mcgill.ca
Background: Phase 2 trials bridge a clinical strategy that shows promise in preclinical
studies to late phase trials that confirm its value. However, high failure rates of these trials …

[PDF][PDF] FARMAKOLOGI TRANSLASIONAL DALAM PENGEMBANGAN OBAT BARU: PERAN DAN PEMANFAATANNYA DALAM MEWUJUDKAN KEMANDIRIAN OBAT …

M Louisa - dgb.ui.ac.id
Kemandirian obat merupakan aspek yang penting dalam memastikan ketersediaan dan
aksesibilitas obat bagi masyarakat di suatu negara. Di Indonesia, salah satu masalah utama …

[HTML][HTML] Your Body, Your Treatment: The Clinical Potential of Microphysiological Systems in Personalized Medicine

L Taye - jhutoxicologypolicyresearch.org
Personalized medicine targets a patient's unique characteristics to provide more accurate
diagnoses and effective treatment. Prevention, diagnosis, and progression for a single …