Lipids constitute the bulk of the dry mass of the brain and have been associated with healthy
function as well as the most common pathological conditions of the brain. Demographic …

Cells in the mammalian body must accurately maintain their content of cholesterol, which is
an essential membrane component and precursor for vital signalling molecules. Outside the …

Parkinson's disease (PD) is the second most progressive neurodegenerative disorder of the
aging population after Alzheimer's disease (AD). Defects in the lysosomal systems and …

Cholesterol is an essential component of both the peripheral nervous system and central
nervous system (CNS) of mammals. Brain cholesterol is synthesized in situ by astrocytes …

The brain is the most lipid-rich organ in the body and, owing to the impermeable nature of
the blood–brain barrier, lipid and lipoprotein metabolism within this organ is distinct from the …

Lipoprotein metabolism in brain has not yet been fully elucidated, although there are a few
reports concerning lipids in the brain and lipoproteins and apolipoproteins in the …

Lipoproteins in cerebrospinal fluid (CSF) of the central nervous system (CNS) resemble
plasma high-density lipoproteins (HDLs), which are a compositionally and structurally …

High-density lipoproteins (HDLs) are a heterogeneous group of lipoproteins composed of
various lipids and proteins. HDL is formed both in the systemic circulation and in the brain. In …

Low plasma levels of HDL-cholesterol (HDL-C) represent a strong and independent risk
factor for cardiovascular disease. HDL particles display a wide spectrum of atheroprotective …

There is no understanding of the role of cholesterol and phospholipids in the mechanisms of
synaptic function and neurodegeneration. Here we report that cholesterol disbalance is …