A neural network-based model framework for cell-fate decisions and development
Gene regulatory networks (GRNs) fulfill the essential function of maintaining the stability of
cellular differentiation states by sustaining lineage-specific gene expression, while driving …
cellular differentiation states by sustaining lineage-specific gene expression, while driving …
The Blueprint of Logical Decisions in a NF-κB Signaling System
Nearly identical cells can exhibit substantially different responses to the same stimulus that
causes phenotype diversity. Such interplay between phenotype diversity and the …
causes phenotype diversity. Such interplay between phenotype diversity and the …
A mathematical framework for understanding the spontaneous emergence of complexity applicable to growing multicellular systems
L Zhang, G Xue, X Zhou, J Huang… - PLOS Computational …, 2024 - journals.plos.org
In embryonic development and organogenesis, cells sharing identical genetic codes acquire
diverse gene expression states in a highly reproducible spatial distribution, crucial for …
diverse gene expression states in a highly reproducible spatial distribution, crucial for …
Operating principles of interconnected feedback loops underlying cell fate decisions
A Hegade, M Rashid - bioRxiv, 2024 - biorxiv.org
Interconnected feedback loops are prevalent across biological mechanisms including cell
fate transitions enabled by epigenetic mechanisms driving phenotypic plasticity of …
fate transitions enabled by epigenetic mechanisms driving phenotypic plasticity of …