Age-related decline in physical and cognitive functions are facts of life that do not affect
everyone to the same extent. We had reported earlier that such cognitive decline is both sex …

Senile osteoporosis increases fracture risks. Bone marrow stromal cells (BMSCs) are
sensitive to aging. Deep insights into BMSCs aging are vital to elucidate the mechanisms …

Mitochondria serve as essential organelles that play a key role in regulating stem cell fate.
Mitochondrial dysfunction and stem cell exhaustion are two of the nine distinct hallmarks of …

Anti-aging strategies extend beyond cosmetic concerns, reaching into the realm of disease
prevention, promoting longevity, and optimizing overall health. The quest for a longer …

The process of aging refers to physiological changes that occur to an organism as time
progresses and involves changes to DNA, proteins, metabolism, cells, and organs. Like the …

Nuclear structure influences genome architecture, which contributes to determine patterns of
gene expression. Global changes in chromatin dynamics are essential during development …

Background In humans, age-related DNA methylation has been studied in blood, tissues,
buccal swabs, and fibroblasts, and changes in DNA methylation patterns according to age …

With increasing age, there is a notable increase in the differentiation of bone marrow-
derived mononuclear cells (BMMs) into osteoclasts, accompanied by a concurrent rise in …

随着人类寿命不断增长, 全球人口老龄化加剧, 老年性疾病发病率也随之上升. 炎性衰老(inflamm-
aging) 指机体随增龄出现的促炎状态升高的现象. 研究表明, 炎性衰老与心脑血管疾病 …

Genetically modified mice are engineered as models for human diseases. These mouse
models include inbred strains, mutants, gene knockouts, gene knockins, and …