Integrated MRI-guided radiotherapy—opportunities and challenges

PJ Keall, C Brighi, C Glide-Hurst, G Liney… - Nature Reviews …, 2022 - nature.com
MRI can help to categorize tissues as malignant or non-malignant both anatomically and
functionally, with a high level of spatial and temporal resolution. This non-invasive imaging …

Roadmap: proton therapy physics and biology

H Paganetti, C Beltran, S Both, L Dong… - Physics in Medicine …, 2021 - iopscience.iop.org
The treatment of cancer with proton radiation therapy was first suggested in 1946 followed
by the first treatments in the 1950s. As of 2020, almost 200 000 patients have been treated …

Medical physics challenges in clinical MR-guided radiotherapy

C Kurz, G Buizza, G Landry, F Kamp, M Rabe… - Radiation …, 2020 - Springer
The integration of magnetic resonance imaging (MRI) for guidance in external beam
radiotherapy has faced significant research and development efforts in recent years. The …

Practical clinical workflows for online and offline adaptive radiation therapy

OL Green, LE Henke, GD Hugo - Seminars in radiation oncology, 2019 - Elsevier
Adaptive radiotherapy emerged over 20 years ago and is now an established clinical
practice in a number of organ sites. No one solution for adaptive therapy exists. Rather …

Magnetic resonance‐guided radiation therapy: a review

S Chin, CL Eccles, A McWilliam… - Journal of medical …, 2020 - Wiley Online Library
Magnetic resonance‐guided radiation therapy (MRgRT) is a promising approach to
improving clinical outcomes for patients treated with radiation therapy. The roles of image …

Deep convolution neural network (DCNN) multiplane approach to synthetic CT generation from MR images—application in brain proton therapy

MF Spadea, G Pileggi, P Zaffino, P Salome… - International Journal of …, 2019 - Elsevier
Purpose The first aim of this work is to present a novel deep convolution neural network
(DCNN) multiplane approach and compare it to single-plane prediction of synthetic …

DeepDose: Towards a fast dose calculation engine for radiation therapy using deep learning

C Kontaxis, GH Bol, JJW Lagendijk… - Physics in Medicine & …, 2020 - iopscience.iop.org
We present DeepDose, a deep learning framework for fast dose calculations in radiation
therapy. Given a patient anatomy and linear-accelerator IMRT multi-leaf-collimator shape or …

Stability of radiomics features in apparent diffusion coefficient maps from a multi-centre test-retest trial

J Peerlings, HC Woodruff, JM Winfield, A Ibrahim… - Scientific reports, 2019 - nature.com
Quantitative radiomics features, extracted from medical images, characterize tumour-
phenotypes and have been shown to provide prognostic value in predicting clinical …

Patient‐specific transfer learning for auto‐segmentation in adaptive 0.35 T MRgRT of prostate cancer: a bi‐centric evaluation

M Kawula, I Hadi, L Nierer, M Vagni… - Medical …, 2023 - Wiley Online Library
Background Online adaptive radiation therapy (RT) using hybrid magnetic resonance linear
accelerators (MR‐Linacs) can administer a tailored radiation dose at each treatment fraction …

MRI-LINAC: A transformative technology in radiation oncology

J Ng, F Gregucci, RT Pennell, H Nagar… - Frontiers in …, 2023 - frontiersin.org
Advances in radiotherapy technologies have enabled more precise target guidance,
improved treatment verification, and greater control and versatility in radiation delivery …