Epithelial Na+ channels (ENaCs) are members of a family of cation channels that function as
sensors of the extracellular environment. ENaCs are activated by specific proteases in the …

Background: Although diuretics are one of the most widely used drugs by nephrologists,
their antiproteinuric properties are not generally taken into consideration. Summary …

Diabetic kidney disease (DKD) is one of the most common causes of end-stage renal
disease worldwide. The treatment of DKD is strongly associated with clinical outcomes in …

The complications of type 2 diabetes are a major global public health problem with high
incidence and mortality, affecting almost all individuals with diabetes worldwide. Diabetic …

Sodium retention and extracellular volume expansion are typical features of patients with
nephrotic syndrome. In recent years, from in vitro data, endoluminal activation of the …

Background: Data on diuretic treatment in nephrotic syndrome (NS) are scarce. Our goal
was to assess the non-inferiority of the combined oral diuretics (furosemide …

Oedema is a defining element of the nephrotic syndrome. Its' management varies
considerably between clinicians, with no national or international clinical guidelines, and …

Sodium retention and edema are hallmarks of nephrotic syndrome (NS). Different
experimental rodent models have been established for simulating NS, however, not all of …

Aim Activation of sodium reabsorption by urinary proteases has been implicated in sodium
retention associated with nephrotic syndrome. The study was designed to test the …

Although the exact mechanisms for proteolytic ENaC activation are not resolved, multiple,
redundant proteases are involved. Experimental and clinical evidence indicate that aberrant …