The aged adaptive immune system is characterized by progressive dysfunction as well as
increased autoimmunity. This decline is responsible for elevated susceptibility to infection …

Although advances in preventive medicine have greatly improved prognosis, cardiovascular
disease (CVD) remains the leading cause of death worldwide. This clearly indicates that …

Whether age-associated defects in T cells impact the immunogenicity and reactogenicity of
mRNA vaccines remains unclear. Using a vaccinated cohort (n= 216), we demonstrated that …

There is a dramatic remodeling of the T cell compartment during aging. The most notorious
changes are the reduction of the naive T cell pool and the accumulation of memory-like T …

CD8+ T cells play a central role in antitumor immune responses that kill cancer cells directly.
In aged individuals, CD8+ T cell immunity is strongly suppressed, which is associated with …

Chimeric antigen receptor (CAR) T cell dysfunction is a major barrier to achieving lasting
remission in hematologic cancers, especially in chronic lymphocytic leukemia (CLL). We …

As an emerging treatment strategy for malignant tumors, chimeric antigen receptor T (CAR-
T) cell therapy has been widely used in clinical practice, and its efficacy has been markedly …

Immunosenescence is a process associated with aging that leads to dysregulation of cells of
innate and adaptive immunity, which may become dysfunctional. Consequently, older adults …

Introduction The incidence of rheumatoid arthritis (RA) and its complications are expected to
increase with age. Remarkably, RA patients were identified features of accelerated aging …

A variety of intrinsic and extrinsic factors contribute to the altered efficiency of CTLs in elderly
organisms. In particular, the efficacy of antiviral CD8+ T cells responses in the elderly has …