N6-methyladenosine demethylase FTO suppressed prostate cancer progression by maintaining CLIC4 mRNA stability
L Zou, W Chen, X Zhou, T Yang, J Luo, Z Long… - Cell Death …, 2022 - nature.com
The fat mass and obesity-associated protein (FTO) is an N6-Methyladenosine (m6A)
demethylase, which has been revealed to play critical roles in tumorigenesis. However, its …
demethylase, which has been revealed to play critical roles in tumorigenesis. However, its …
The Macrophage-Associated LncRNA MALR Facilitates ILF3 Liquid–Liquid Phase Separation to Promote HIF1α Signaling in Esophageal Cancer
J Liu, ZX Liu, JJ Li, ZL Zeng, JH Wang, XJ Luo… - Cancer Research, 2023 - AACR
Tumor-associated macrophages (TAM) are among the most abundant immune cells in the
tumor microenvironment and are important mediators of tumor development and …
tumor microenvironment and are important mediators of tumor development and …
[HTML][HTML] Regulatory mechanisms and therapeutic implications of insulin-like growth factor 2 mRNA-binding proteins, the emerging crucial m6A regulators of tumors
H Zhou, Q Sun, M Feng, Z Gao, S Jia, L Cao, X Yu… - Theranostics, 2023 - ncbi.nlm.nih.gov
Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) serve essential biological
functions as post-transcriptional performers, participating in the acquisition or maintenance …
functions as post-transcriptional performers, participating in the acquisition or maintenance …
[HTML][HTML] M6A-modified circRBM33 promotes prostate cancer progression via PDHA1-mediated mitochondrial respiration regulation and presents a potential target for …
C Zhong, Z Long, T Yang, S Wang… - … Journal of Biological …, 2023 - ncbi.nlm.nih.gov
Abstract N6-Methyladenosine (m6A) is the most prevalent RNA modification in various types
of RNA, including circular RNAs (circRNAs). Mounting evidence has shown that circRNAs …
of RNA, including circular RNAs (circRNAs). Mounting evidence has shown that circRNAs …
[HTML][HTML] ELK1-mediated YTHDF1 drives prostate cancer progression by facilitating the translation of Polo-like kinase 1 in an m6A dependent manner
P Li, Y Shi, D Gao, H Xu, Y Zou, Z Wang… - International Journal of …, 2022 - ncbi.nlm.nih.gov
Background: N6-methyladenosine (m6A) is one of the most prevalent mRNA modifications
in mammals, and it regulates the fate of modified RNA transcripts. In the current study, we …
in mammals, and it regulates the fate of modified RNA transcripts. In the current study, we …
The functions and mechanisms of post-translational modification in protein regulators of RNA methylation: Current status and future perspectives
Y Chen, Z Jiang, Y Yang, C Zhang, H Liu… - International Journal of …, 2023 - Elsevier
RNA methylation, an epigenetic modification that does not alter gene sequence, may be
important to diverse biological processes. Protein regulators of RNA methylation include …
important to diverse biological processes. Protein regulators of RNA methylation include …
RNA m6A methylation in cancer
Z Wang, J Zhou, H Zhang, L Ge, J Li… - Molecular …, 2023 - Wiley Online Library
N 6‐methyladenosine (m6A) is one of the most abundant internal modifications in eukaryotic
messenger RNAs (mRNAs) and non‐coding RNAs (ncRNAs). It is a reversible and dynamic …
messenger RNAs (mRNAs) and non‐coding RNAs (ncRNAs). It is a reversible and dynamic …
Crosstalk between m6A regulators and mRNA during cancer progression
Abstract m6A modification, the most abundant and widespread RNA modification, is present
and involved in the occurrence and development of various cancers. To date, most studies …
and involved in the occurrence and development of various cancers. To date, most studies …
FTO inhibits epithelial ovarian cancer progression by destabilising SNAI1 mRNA through IGF2BP2
M Sun, X Zhang, F Bi, D Wang, X Zhou, X Li, Q Yang - Cancers, 2022 - mdpi.com
Simple Summary Ovarian cancer is the gynaecologic malignant tumour with the highest
mortality. Most patients are already in the advanced stage when they are found, and the 5 …
mortality. Most patients are already in the advanced stage when they are found, and the 5 …
[HTML][HTML] Novel insights into m6A modification of coding and non-coding RNAs in tumor biology: From molecular mechanisms to therapeutic significance
J Jia, S Wu, Z Jia, C Wang, C Ju, J Sheng… - … Journal of Biological …, 2022 - ncbi.nlm.nih.gov
Accumulating evidence has revealed that m 6 A modification, the predominant RNA
modification in eukaryotes, adds a novel layer of regulation to the gene expression. Dynamic …
modification in eukaryotes, adds a novel layer of regulation to the gene expression. Dynamic …