Genetic correlations of polygenic disease traits: from theory to practice
W Van Rheenen, WJ Peyrot, AJ Schork… - Nature Reviews …, 2019 - nature.com
The genetic correlation describes the genetic relationship between two traits and can
contribute to a better understanding of the shared biological pathways and/or the causality …
contribute to a better understanding of the shared biological pathways and/or the causality …
Developing and evaluating polygenic risk prediction models for stratified disease prevention
Abstract Knowledge of genetics and its implications for human health is rapidly evolving in
accordance with recent events, such as discoveries of large numbers of disease …
accordance with recent events, such as discoveries of large numbers of disease …
Detection and interpretation of shared genetic influences on 42 human traits
We performed a scan for genetic variants associated with multiple phenotypes by comparing
large genome-wide association studies (GWAS) of 42 traits or diseases. We identified 341 …
large genome-wide association studies (GWAS) of 42 traits or diseases. We identified 341 …
[HTML][HTML] Understanding the genetic determinants of the brain with MOSTest
Regional brain morphology has a complex genetic architecture, consisting of many common
polymorphisms with small individual effects. This has proven challenging for genome-wide …
polymorphisms with small individual effects. This has proven challenging for genome-wide …
Polygenic scores via penalized regression on summary statistics
Polygenic scores (PGS) summarize the genetic contribution of a person's genotype to a
disease or phenotype. They can be used to group participants into different risk categories …
disease or phenotype. They can be used to group participants into different risk categories …
Performance measures in evaluating machine learning based bioinformatics predictors for classifications
Y Jiao, P Du - Quantitative Biology, 2016 - Springer
Background Many existing bioinformatics predictors are based on machine learning
technology. When applying these predictors in practical studies, their predictive …
technology. When applying these predictors in practical studies, their predictive …
Genome-wide pleiotropy between Parkinson disease and autoimmune diseases
Importance Recent genome-wide association studies (GWAS) and pathway analyses
supported long-standing observations of an association between immune-mediated …
supported long-standing observations of an association between immune-mediated …
Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia
Bipolar disorder and schizophrenia are two often severe disorders with high heritabilities.
Recent studies have demonstrated a large overlap of genetic risk loci between these …
Recent studies have demonstrated a large overlap of genetic risk loci between these …
Discovery of shared genomic loci using the conditional false discovery rate approach
In recent years, genome-wide association study (GWAS) sample sizes have become larger,
the statistical power has improved and thousands of trait-associated variants have been …
the statistical power has improved and thousands of trait-associated variants have been …
[HTML][HTML] Genome-wide association study of eosinophilic granulomatosis with polyangiitis reveals genomic loci stratified by ANCA status
PA Lyons, JE Peters, F Alberici, J Liley… - Nature …, 2019 - nature.com
Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare inflammatory disease of
unknown cause. 30% of patients have anti-neutrophil cytoplasmic antibodies (ANCA) …
unknown cause. 30% of patients have anti-neutrophil cytoplasmic antibodies (ANCA) …