During the past few years, unexpected developments have driven studies in the field of
clinical immunology. One driver of immense impact was the outbreak of a pandemic caused …

Background Since the beginning of the COVID-19 pandemic, several variants of concern
(VOC) have emerged for which there is evidence of an increase in transmissibility, more …

Introduction SARS-CoV-2, the cause of the COVID pandemic, is an RNA virus with a high
propensity to mutate. Successive virus variants, including variants of concern (VOC), have …

To identify starting points for therapeutics targeting SARS-CoV-2, the Paul Scherrer Institute
and Idorsia decided to collaboratively perform an X-ray crystallographic fragment screen …

The constant emergence of variants of concern (VOCs) challenges the effectiveness of
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines over time. This is …

Developing effective vaccines against viral infections have significant impacts on
development, prosperity and well-being of human populations. Thus, successful vaccines …

Background The evolving variants of SARS-CoV-2 may escape immunity from prior
infections or vaccinations. It's vital to understand how immunity adapts to these changes …

Background Within a year of the SARS-CoV-2 pandemic, vaccines inducing a robust
humoral and cellular immune response were implemented worldwide. However, emergence …

The continual evolution of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-
2) and the emergence of variants that show resistance to vaccines and neutralizing …

Variants of SARS-CoV-2 pose significant challenges in public health due to their increased
transmissibility and ability to evade natural immunity, vaccine protection, and monoclonal …