[HTML][HTML] Biological mechanisms underpinning the development of long COVID

R Perumal, L Shunmugam, K Naidoo, D Wilkins… - Iscience, 2023 - cell.com
As COVID-19 evolves from a pandemic to an endemic disease, the already staggering
number of people that have been or will be infected with SARS-CoV-2 is only destined to …

[HTML][HTML] SARS-CoV-2 placentitis, stillbirth, and maternal COVID-19 vaccination: clinical–pathologic correlations

DA Schwartz, SB Mulkey, DJ Roberts - American journal of obstetrics and …, 2023 - Elsevier
Stillbirth is a recognized complication of COVID-19 in pregnant women that has recently
been demonstrated to be caused by SARS-CoV-2 infection of the placenta. Multiple global …

From cytokine storm to cytokine breeze: did lessons learned from immunopathogenesis improve immunomodulatory treatment of moderate-to-severe COVID-19?

G Rondovic, D Djordjevic, I Udovicic, I Stanojevic… - Biomedicines, 2022 - mdpi.com
Complex immune response to infection has been highlighted, more than ever, during the
COVID-19 pandemic. This review explores the immunomodulatory treatment of moderate-to …

SARS-CoV-2 viremia and COVID-19 mortality: A prospective observational study

A Giacomelli, E Righini, V Micheli, P Pinoli… - PLoS …, 2023 - journals.plos.org
Background SARS-CoV-2 viremia has been found to be a potential prognostic factor in
patients hospitalized for COVID-19. Objective We aimed to assess the association between …

The kinetics of SARS-CoV-2 antibody development is associated with clearance of RNAemia

C Wang, Y Li, P Kaplonek, M Gentili, S Fischinger… - Mbio, 2022 - Am Soc Microbiol
Persistent SARS-CoV-2 replication and systemic dissemination are linked to increased
COVID-19 disease severity and mortality. However, the precise immune profiles that track …

SARS-CoV-2 variant delta potently suppresses innate immune response and evades interferon-activated antiviral responses in human colon epithelial cells

D Tandel, V Sah, NK Singh, PS Potharaju… - Microbiology …, 2022 - Am Soc Microbiol
The Delta variant of SARS-CoV-2 has caused more severe infections than its previous
variants. We studied the host innate immune response to Delta, Alpha, and two earlier …

Effects of remdesivir on SARS-CoV-2 viral dynamics and mortality in viraemic patients hospitalized for COVID-19

K Hagman, M Hedenstierna, J Widaeus… - Journal of …, 2023 - academic.oup.com
Background Studies on the antiviral effects of remdesivir have shown conflicting results.
SARS-CoV-2 viraemia could identify patients in whom antiviral treatment may be particularly …

High viral loads: what drives fatal cases of COVID-19 in vaccinees?–an autopsy study

K Hirschbühl, T Schaller, B Märkl, R Claus, E Sipos… - Modern …, 2022 - nature.com
The rate of SARS-CoV-2 infections in vaccinees has become a relevant serious issue. This
study aimed to determine the causes of death, histological organ alteration, and viral spread …

Struggling with Covid-19 in adult inborn errors of immunity patients: A case series of combination therapy and multiple lines of therapy for selected patients

P Bez, G D'ippolito, CM Deiana, R Finco Gambier… - Life, 2023 - mdpi.com
Background: The SARS-CoV-2 infection is now a part of the everyday lives of
immunocompromised patients, but the choice of treatment and the time of viral clearance …

Plasma SARS-CoV-2 RNA levels as a biomarker of lower respiratory tract SARS-CoV-2 infection in critically ill patients with COVID-19

JL Jacobs, A Naqvi, FA Shah, VF Boltz… - The Journal of …, 2022 - academic.oup.com
Abstract Plasma SARS-CoV-2 viral RNA (vRNA) levels are predictive of COVID-19
outcomes in hospitalized patients, but whether plasma vRNA reflects lower respiratory tract …