DNA double-strand break repair-pathway choice in somatic mammalian cells
The major pathways of DNA double-strand break (DSB) repair are crucial for maintaining
genomic stability. However, if deployed in an inappropriate cellular context, these same …
genomic stability. However, if deployed in an inappropriate cellular context, these same …
Methodologies for improving HDR efficiency
M Liu, S Rehman, X Tang, K Gu, Q Fan, D Chen… - Frontiers in …, 2019 - frontiersin.org
Clustered regularly interspaced short palindromic repeats (CRISPR)-associated protein 9
(Cas9) is a precise genome manipulating technology that can be programmed to induce …
(Cas9) is a precise genome manipulating technology that can be programmed to induce …
Mechanisms underlying structural variant formation in genomic disorders
CMB Carvalho, JR Lupski - Nature Reviews Genetics, 2016 - nature.com
With the recent burst of technological developments in genomics, and the clinical
implementation of genome-wide assays, our understanding of the molecular basis of …
implementation of genome-wide assays, our understanding of the molecular basis of …
Break-induced telomere synthesis underlies alternative telomere maintenance
Homology-directed DNA repair is essential for genome maintenance through templated
DNA synthesis. Alternative lengthening of telomeres (ALT) necessitates homology-directed …
DNA synthesis. Alternative lengthening of telomeres (ALT) necessitates homology-directed …
RAD52 facilitates mitotic DNA synthesis following replication stress
R Bhowmick, S Minocherhomji, ID Hickson - Molecular cell, 2016 - cell.com
Homologous recombination (HR) is necessary to counteract DNA replication stress.
Common fragile site (CFS) loci are particularly sensitive to replication stress and undergo …
Common fragile site (CFS) loci are particularly sensitive to replication stress and undergo …
Replication-coupled DNA repair
D Cortez - Molecular cell, 2019 - cell.com
The replisome quickly and accurately copies billions of DNA bases each cell division cycle.
However, it can make errors, especially when the template DNA is damaged. In these cases …
However, it can make errors, especially when the template DNA is damaged. In these cases …
Break-induced replication: the where, the why, and the how
Break-induced replication (BIR) is a pathway that repairs one-ended double-strand breaks
(DSBs). For decades, yeast model systems offered the only opportunities to study eukaryotic …
(DSBs). For decades, yeast model systems offered the only opportunities to study eukaryotic …
RAD51 Gene Family Structure and Function
B Bonilla, SR Hengel, MKK Grundy… - Annual review of …, 2020 - annualreviews.org
Accurate DNA repair and replication are critical for genomic stability and cancer prevention.
RAD51 and its gene family are key regulators of DNA fidelity through diverse roles in double …
RAD51 and its gene family are key regulators of DNA fidelity through diverse roles in double …
Mammalian RAD52 functions in break-induced replication repair of collapsed DNA replication forks
Human cancers are characterized by the presence of oncogene-induced DNA replication
stress (DRS), making them dependent on repair pathways such as break-induced …
stress (DRS), making them dependent on repair pathways such as break-induced …
Fork cleavage-religation cycle and active transcription mediate replication restart after fork stalling at co-transcriptional R-loops
N Chappidi, Z Nascakova, B Boleslavska, R Zellweger… - Molecular cell, 2020 - cell.com
Formation of co-transcriptional R-loops underlies replication fork stalling upon head-on
transcription-replication encounters. Here, we demonstrate that RAD51-dependent …
transcription-replication encounters. Here, we demonstrate that RAD51-dependent …