Computational oncology is a generic term that encompasses any form of computer-based
modelling relating to tumour biology and cancer therapy. Mathematical modelling can be …

Metronomic chemotherapy describes the close, regular administration of chemotherapy
drugs at less-toxic doses over prolonged periods of time. In 2015, the results of randomized …

Therapeutic drug monitoring (TDM) provides valuable guidance for dose adjustment of
antibiotics, immunosuppressives, antiepileptics, and other drugs, but its use for traditional …

The average weight of adults in the U nited S tates has increased by 25 pounds (11 kg) over
the past 50 years, with a marginal change in height. Drugs are generally dosed according to …

Current methods of drug dosing rely on physical parameters (such as sex, age and weight)
that do not account for genetic and physiological differences among individual patients …

Molecular targeted therapies with tyrosine kinase inhibitors (TKIs) have been a recent
breakthrough in cancer treatment. These small molecules are mainly used at a fixed dose …

Clinical drug dosing would, ideally, be informed by high-precision, patient-specific data on
drug metabolism. The direct determination of patient-specific drug pharmacokinetics (“peaks …

The availability of high-fidelity animal models for oncology research has grown enormously
in recent years, enabling preclinical studies relevant to prevention, diagnosis, and treatment …

Objectives To evaluate the clinical significance of interventions made by pharmacists in an
oncology pharmacy in Singapore and their acceptance rate and to identify common drug …

Aims The aims of the study were:(i) to characterize the pharmacokinetics (PK) of doxorubicin
(DOX) and doxorubicinol (DOXol) in patients diagnosed with non‐Hodgkin's lymphoma …