Urinary bladder smooth muscle (UBSM), also known as detrusor smooth muscle, forms the
bladder wall and ultimately determines the two main attributes of the organ: urine storage …

K v 7 (“M-type,” KCNQ) K+ currents, play dominant roles in controlling neuronal excitability.
They act as a “brake” against hyperexcitable states in the central and peripheral nervous …

Nearly three million people in the USA suffer traumatic brain injury (TBI) yearly; however,
there are no pre-or post-TBI treatment options available. KCNQ2-5 voltage-gated K+ …

Abstract Kv7. 1-Kv7. 5 (KCNQ1–5) K+ channels are voltage-gated K+ channels with major
roles in neurons, muscle cells and epithelia where they underlie physiologically important …

Storage and voiding functions in urinary bladder are well-known, yet fundamental
physiological events coordinating these behaviors remain elusive. We sought to understand …

Retigabine is unique among anticonvulsant drugs by targeting the neuronal M-channel,
which is composed of KV7. 2/KV7. 3 and contributes to the negative neuronal resting …

Purinergic contractions of the detrusor are reduced by cAMP, but the underlying
mechanisms are unclear. We examined the effects of BK and Kv7 channel modulators on …

Optimal bladder compliance is essential to urinary bladder storage and voiding functions.
Calculated as the change in filling volume per change in pressure, bladder compliance is …

Retigabine is a first-in-class potassium channel opener approved for patients with epilepsy.
Unfortunately, several side effects have limited its use in clinical practice, overshadowing its …

Relaxation and contraction of the urinary bladder smooth muscle, also known as the
detrusor smooth muscle (DSM), facilitate the micturition cycle. DSM contractility depends on …