Food-derived 1, 2-dicarbonyl compounds and their role in diseases

M Hellwig, S Gensberger-Reigl, T Henle… - Seminars in cancer …, 2018 - Elsevier
Abstract Reactive 1, 2-dicarbonyl compounds (DCs) are generated from carbohydrates
during food processing and storage and under physiological conditions. In the recent …

Active mitochondrial respiration in cancer: a target for the drug

M Bedi, M Ray, A Ghosh - Molecular and Cellular Biochemistry, 2022 - Springer
The relative contribution of mitochondrial respiration and subsequent energy production in
malignant cells has remained controversial to date. Enhanced aerobic glycolysis and …

Cold atmospheric plasma conveys selectivity on triple negative breast cancer cells both in vitro and in vivo

L Xiang, X Xu, S Zhang, D Cai, X Dai - Free Radical Biology and Medicine, 2018 - Elsevier
Breast cancers are heterogeneous, with the triple negative subtype being the most
aggressive and lack of effective therapy. Cold atmospheric plasma has become a promising …

Small-molecule redox modulators with anticancer activity: A comprehensive mechanistic update

C Pal - Free Radical Biology and Medicine, 2023 - Elsevier
The pursuit of effective anticancer therapies has led to a burgeoning interest in the realm of
redox modulation. This review provides a comprehensive exploration of the intricate …

[HTML][HTML] Glyoxalases in urological malignancies

C Antognelli, VN Talesa - International journal of molecular sciences, 2018 - mdpi.com
Urological cancers include a spectrum of malignancies affecting organs of the reproductive
and/or urinary systems, such as prostate, kidney, bladder, and testis. Despite improved …

Pterostilbene inhibited advanced glycation end products (AGEs)-induced oxidative stress and inflammation by regulation of RAGE/MAPK/NF-κB in RAW264. 7 cells

W Yu, X Hu, M Wang - Journal of Functional Foods, 2018 - Elsevier
Pterostilbene is a natural stilbene compound found in blueberries. It has been found to show
anticancer, anti-inflammatory and anti-oxidative effects. However, little is known about its …

Classically activated mouse macrophages produce methylglyoxal that induces a TLR4-and RAGE-independent proinflammatory response

D Prantner, S Nallar, K Richard… - Journal of Leucocyte …, 2021 - academic.oup.com
The highly reactive compound methylglyoxal (MG) can cause direct damage to cells and
tissues by reacting with cellular macromolecules. MG has been identified as a biomarker …

[HTML][HTML] Sclareol is a potent enhancer of doxorubicin: Evaluation of the free combination and co-loaded nanostructured lipid carriers against breast cancer

GSM Borges, J de Oliveira Silva, RS Fernandes… - Life sciences, 2019 - Elsevier
Aims In this work, it was sought to determine if there was synergism between doxorubicin
(DOX), a well-known antineoplastic, and sclareol (SC), a diterpene from natural origin, in …

Activatable NIR-II fluorescent nanoprobe for rapid detection and imaging of methylglyoxal facilitated by the local nonpolar microenvironment

Y Dang, Y Lai, F Chen, Q Sun, C Ding… - Analytical …, 2022 - ACS Publications
Closely related to multiple chronic inflammation, especially type-2 diabetes (T2D),
methylglyoxal (MGO) may be a potential key to visualize disease progression and treatment …

Rubioncolin C, a natural naphthohydroquinone dimer isolated from Rubia yunnanensis, inhibits the proliferation and metastasis by inducing ROS-mediated apoptotic …

L Li, J Wang, L Feng, J Fan, J Wang, N Tan… - Journal of …, 2021 - Elsevier
Abstract Ethnopharmacological relevance Rubia yunnanensis Diels is a traditional Chinese
medicine that has diverse pharmacological activities, including antituberculosis …