Successful human reproduction requires gamete maturation, fertilization, and early
embryonic development. Human oocyte maturation includes nuclear and cytoplasmic …

Idiopathic or “unexplained” infertility represents as many as 30% of infertility cases
worldwide. Conception, implantation, and term delivery of developmentally healthy infants …

Zygotic cleavage failure (ZCF) is a unique early embryonic phenotype resulting in female
infertility and recurrent failure of in vitro fertilization (IVF) and/or intracytoplasmic sperm …

BACKGROUND Our genetic code is now readable, writable and hackable. The recent
escalation of genome-wide sequencing (GS) applications in population diagnostics will not …

The pool of primordial follicles formed in the ovaries during early development determines
the span and quality of fertility in the reproductive life of a woman. As exposure to …

Infertility or subfertility is a critical barrier to sustainable cattle production, including in heifers.
The development of heifers that do not produce a calf within an optimum window of time is a …

Various pathogenic factors can lead to oogenesis failure and seriously affect both female
reproductive health and fertility. Genetic factors play an important role in folliculogenesis and …

In meiosis, homologous chromosome synapsis is mediated by a supramolecular protein
structure, the synaptonemal complex (SC), that assembles between homologous …

Maternal effect genes (MEGs) encode factors (eg, RNA) that are present in the oocyte and
required for early embryonic development. Hence, while these genes and gene products are …

DNA repair processes are critical to maintaining genomic integrity. As a result, dysregulation
of repair genes is likely to be linked with health implications, such as an increased …