Uromodulin, a protein exclusively produced by the kidney, is the most abundant urinary
protein in physiological conditions. Already described several decades ago, uromodulin has …

All mammalian oocytes and eggs are surrounded by a relatively thick extracellular matrix
(ECM), the zona pellucida (ZP), that plays vital roles during oogenesis, fertilization, and …

The Drosophila corneal lens is entirely composed of chitin and other apical extracellular
matrix components, and it is not known how it acquires the biconvex shape that enables it to …

Sexual reproduction is such a successful way of creating progeny with subtle genetic
variations that the vast majority of eukaryotic species use it. In mammals, it involves the …

The exclusive expression of uromodulin in the kidneys has made it an intriguing protein in
kidney and cardiovascular research. Genome-wide association studies discovered variants …

Abstract Glycoprotein 2 (GP2) and uromodulin (UMOD) filaments protect against
gastrointestinal and urinary tract infections by acting as decoys for bacterial fimbrial lectin …

Uromodulin (or Tamm-Horsfall protein) is a glycoprotein uniquely produced in the kidney by
tubular cells of the thick ascending limb of the loop of Henle and early distal tubules. This …

The glycoprotein uromodulin (UMOD) is the most abundant protein in human urine and
forms filamentous homopolymers that encapsulate and aggregate uropathogens, promoting …

Following the fertilization of an egg by a single sperm, the egg coat or zona pellucida (ZP)
hardens and polyspermy is irreversibly blocked. These events are associated with the …

Viral entry and fertilization are distinct biological processes that share a common
mechanism: membrane fusion. In viral entry, enveloped viruses attach to the host cell …