Airway structure and function are key aspects of normal lung development, growth, and
aging, as well as of lung responses to the environment and the pathophysiology of important …

Airway hyperresponsiveness (AHR) is characterized by excessive bronchoconstriction in
response to nonspecific stimuli, thereby leading to airway stenosis and increased airway …

Fibrosis refers to the hardening or scarring of tissues that usually results from aberrant
wound healing in response to organ injury, and its manifestations in various organs have …

Overexpression of interleukin 6 (IL-6) has been proposed to contribute to pulmonary fibrosis
and other fibrotic diseases. However, the regulatory mechanisms and the role of IL-6 in …

Background: Airway remodeling (AR) is a prominent feature of asthma and other obstructive
lung diseases that is minimally affected by current treatments. The goals of this Official …

Fibrosis refers to the scarring and hardening of tissues, which results from a failed immune
system-coordinated wound healing response to chronic organ injury and which manifests …

Purpose Diesel exhaust particles (DEPs) can induce and trigger airway
hyperresponsiveness (AHR) and inflammation. The aim of this study was to investigate the …

Cellular senescence is a complicated process featured by irreversible cell cycle arrest and
senescence-associated secreted phenotype (SASP), resulting in accumulation of senescent …

Asthma (chronic allergic airways disease, AAD) is characterized by airway inflammation (AI),
airway remodeling (AWR) and airway hyperresponsiveness (AHR). Current treatments for …

Lung inflammation and oxidative stress are the major contributors to the development of
obstructive pulmonary diseases. Macrophages are involved in pulmonary inflammation and …